Nanomedicina si vaccinul terapeutic n infecia cu virusul HIVCicala Ecaterina, an III

Cuvinte-cheieVaccin terapeutic

HIV-SIDA

Cuvinte-cheieTerapie antiretroviral combinat (cART combinated antiretroviral therapy)Celule Langerhans, celule dendriticeImunogenitatepADN (plasmid ADN)VLP (virus-like particle)

Vaccinul terapeutic pe baza celulelor dendriticePuncte slabeProcedur laborioasDuratRisc

NanoparticulaPEIm polietilenimin manozilat

API active pharmaceutical ingredient

Conceptul

Lisziewicz J, Bakare N, Calarota SA, Bnhegyi D, et al. (2012) Single DermaVir Immunization: Dose-Dependent Expansion of Precursor/Memory T Cells against All HIV Antigens in HIV-1 Infected Individuals. PLoS ONE 7(5): e35416. doi:10.1371/journal.pone.0035416http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035416

Puncte forte+ reactii adverse minime+ schem terapeutica simpl

Puncte slabeVariabilitate viralVariabilitate genetic a pacientului (rspunsul imun) SolutieTratament personalizat Soft de prelucrare a datelor genetice si a tipului HIVCost-eficient (?)

Bibliografie1. Julianna Lisziewicz, PhD, Enik R. Tke, PhD, Nanomedicine applications towards the cure of HIV, Nanomedicine: Nanotechnology, Biology, and Medicine 9 (2013) 2838, received 10 February 2012; accepted 16 May 2012 2. Gh.Coman, M.Badea, N.Bigiu, A.Vlceanu Matei, Biochimie Clinic. Enzimologie, Ed.Univ.Transilv. din Braov, 20123. Fauci, Braunwals, Isselbacher, Wilson, Martin, Kasper, Hauser, Lougo Principii de Medicin Intern a lui Harrison, Ediia a XIV-a, Ed. Teora, Bucureti, 20034. Arthur C. Guyton, John E. Hall, Tratat de Fiziologie a Omului, Ediia a XI-a, Editura Medical Callisto, 20075. I. Fulga Farmacologie, Editura Medicala, 20066. Julianna Lisziewicz, PhD, DermaVir Immunotherapy Towards HIV Eradication, geneticimmunity.com, December 6, 2012