informaŢii iacob razvan andrei personale€¦ · 2002 diploma de licenta: 430/ 13.03.2002 seria t...

Curriculum Vitae Iacob Razvan Andrei

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 1 / 14

INFORMAŢII PERSONALE

IACOB RAZVAN ANDREI

Adresa (spital): Centrul pentru Boli Digestive si Transplant Hepatic

Institutul Clinic Fundeni Şoseaua Fundeni nr. 258 022328 Bucureşti, România

+4021 2750500(centrala); Fax: +40213180447(secretariat);

[email protected]

Sexul M | Data naşterii 20/11/1976 | Naţionalitatea romana

EXPERIENŢA PROFESIONALĂ

EDUCAŢIE ŞI

FORMARE

2002 Diploma de licenta: 430/ 13.03.2002 Seria T Nr. 0028346 Romania. Absolvent UMF „Carol Davila Bucuresti”, Facultatea de Medicina.

2002 Medic rezident gastroenterologie, Certificat 115/ 12.12.2002 2007 Medic specialist gastroenterologie: OMS 2140/2007 2013 Medic primar gastroenterologie: OMS 1044/2013

Etape medicale si

In prezent

Pozitia ocupata: Sef de Lucrari. Medic primar gastroenterologie Tipul sau sectorul de activitate: Invatamant medical. Asistenta medicala de specialitate, gastroenterologie

2016-prezent Sef de Lucrari gastroenterologie, prin concurs. Universitatea de Medicina si Farmacie „Carol Davila” Bucuresti, Disciplina Gastroenterologie si Hepatologie, Institutul Clinic Fundeni, Catedra M46, Departamentul 5.

2013 -prezent Medic primar gastroenterologie - OMS 1044/2013 2007 - 2013 Medic specialist gastroenterologie - OMS 2140/2007. Centrul pentru Boli

Digestive si Transplant Hepatic, Institutul Clinic Fundeni, Bucuresti. 2006 - 2016 Asistent universitar gastroenterologie, prin concurs, Decizia Nr 10063/1.10.2006.

Universitatea de Medicina si Farmacie „Carol Davila” Bucuresti, Disciplina Gastroenterologie si Hepatologie, Institutul Clinic Fundeni, Catedra M46

2002-2006 Medic rezident gastroenterologie - Certificat 115/ 12.12.2002. Centrul pentru Boli Digestive si Transplant Hepatic, Institutul Clinic Fundeni, Bucuresti.

2003-2006 Preparator universitar, prin concurs. Universitatea de Medicina si Farmacie „Carol Davila” Bucuresti, Disciplina Gastroenterologie si Hepatologie, Institutul Clinic Fundeni



universitare 1995-2001 Universitatea de Medicina si Farmacie „Carol Davila” Bucuresti

2002

Diploma de licenta Nr 430/14.03.2002, Titlul de Doctor - Medic, absolvent UMF „Carol Davila Bucuresti”, Facultatea de Medicina.

2001-2002 Centrul de Gastroenterologie si Hepatologie Fundeni: 2 stagii clinice - medicina interna si chirurgie

2003-2006

Universitatea de Medicina si Farmacie „Carol Davila” Bucuresti: Preparator universitar

2002-2007 Centrul de Gastroenterologie si Hepatologie Fundeni: medic rezident gastroenterologie

2006-2016 Universitatea de Medicina si Farmacie „Carol Davila” Bucuresti – asistent universitar

2007-2013 Centrul de Gastroenterologie si Hepatologie Fundeni: medic specialist gastroenterologie

2010 Doctor in Medicina. Ordin MECTS Nr 4387/06.06.2011. Titlul Tezei de Doctorat: „Rolul factorilor de transcriptie hepatici in procesul de diferentiere hepatocitara”. Coordonator: Prof. Dr. Irinel Popescu

2016-Prezent Universitatea de Medicina si Farmacie „Carol Davila” Bucuresti – Sef de Lucrari

Afiliere la societati si publicatii profesionale

2001 - in prezent Membru al Societatii Romane de Gastroenterologie & Hepatologie (SRGH) 2001 – in prezent Membru al Societatii Romane de Endoscopie Digestiva

(SRED) 2007 – in prezent Membru al Societatii Americane de Endoscopie Gastrointestinala - American

Society for Gastrointestinal Endoscopy (ASGE) 2007- in prezent Membru al Clubului Roman de Boala Crohn si Colita Ulcerativa (RCCC) 2007- in prezent Membru al Societatii Europene de Crohn si Colita (European Crohn’s and Colitis

Organization) (ECCO) 2014 – in prezent Membru al European Association for the Study of the Liver (EASL)

COMPETENΤE PERSONALE



Limba(i) maternă(e)

Romana

Alte limbi străine cunoscute ΙNΤELEGERE VORBIRE SCRIERE

Ascultare Citire Participare la conversaţie Discurs oral

Engleza C2 C2 C2 C2 C2

Franceza C1 C1 C1 C1 C1

Germana C1 C1 C1 C1 C1 Scrieţi denumirea certificatului. Scrieţi nivelul, dacă îl cunoaşteţi. Niveluri: A1/2: Utilizator elementar - B1/2: Utilizator independent - C1/2: Utilizator experimentat

Cadrul european comun de referinţă pentru limbi străine

Competenţe de comunicare ▪ Bune competenţe de comunicare dobândite prin experienţa in cadrul activitatii didactice si clinice de peste 12 ani, participant cu lucrari de specialitate la numeroase manifestari stiintifice internationale si nationale ▪ Autor de lucrari publicate in reviste cu peer review si recenzori internationali

Functii administrative si de conducere

2007-2009 2013-2017

Secretar al Clubului Roman de Boala Crohn si Colita Ulcerativa – Romanian Crohns and Colitis Club (RCCC)

Competente dobandite la locul de munca

Endoscopie digestiva diagnostica (abilitate inclusa in standardul profesional). Ultrasonografie generala (abilitate inclusa in standardul profesional). Endoscopie digestiva terapeutica: Curs postuniversitar de perfectionare, Certificat de absolvire Nr 789/28.10.2008. Atestat de studii complementare. Seria C Nr 032207. Nr de inregistrare 34127/30.05.2013

Competente informatice Utilizator experimentat PC (MS Office, Windows). Permis de conducere: Categoria B1.

Pregătire postuniversitară (CURSURI ŞI

SPECIALIZĂRI)

1 Noiembrie 2000 Curs Precongres: Simpozionul National de Gastroenterologie, Hepatologie si Endoscopie Digestiva, Bucuresti, 2000

Aprilie 2001 EASL Post-Graduate Course: Clinical Management of Portal Hypertension and Its Complications, 36-th EASL Meeting, Prague, CZECH REPUBLIC

Iunie 2003 ESMO Summer Educational Conference, Edinburgh, Scotland, UK 17-18 Martie 2003 Curs postuniversitar: “ Tehnica de montare endoscopica a gastrostomei percutane”



Septembrie 2003 PRECONGRESS COURSE “Actualities in gastroenterology and hepatology”, 9th Congress of Gastroenterology, Hepatology and Gastrointestinal Endoscopy, Craiova, Romania

Octombrie 2003 ADVANCED POSTGRADUATE COURSE IN GASTROENTEROLOGY organized by The Holland Digestive Disease Week Foundation, The Netherlands

Decembrie 2003 EASL School of Hepatology Course 1 – Chronic Liver Diseases Geneva, Switzerland

3-4 aprilie 2004 POSTGRADUATE COURSE IN HEPATO-GASTROENTEROLOGY organized by The National French Society of Gastroenterology, Paris, FRANCE

12 Martie 2004 European Postgraduate Gastro-surgical School, 4th Amsterdam International Update on Hepatology: Hepatitis B and C and Hepatocellular Carcinoma, Academic Medical Center, Amsterdam, The Netherlands

Aprilie 2004 Journees Francophones de Patologie Digestive – stagiu clinic practic de 2 saptamani – Hopital Huriez, Lille, Franta

15-19 Martie 2004 PENTAX – Magnification chromo-colonoscopy - 1 week stagium. Ostrava NIH, Republica Ceha

Septembrie 2004 PRECONGRESS COURSE: The XXVth National Symposium of Gastroenterology, Hepatology and Gastrointestinal Endoscopy, Constanta, Romania

Septembrie 2004 ERASMUS teaching bursary, Gastroenterology Department, Philipps University, Marburg, Germania

25 Septembrie 2004 EASL Post-Graduate Course: Liver Transplantation – State of the Art and Novel Developments, 12th UEGW, Praga, Republica Ceha

11-12 Noiembrie 2004 Curs de Nutritie Clinica si Metabolism, Poiana Brasov, Romania 13-14 Aprilie 2005 EASL Post-Graduate Course: The Liver Clinic in the Post-Genomic Era, 40th EASL

Meeting, Paris, Franta Noiembrie 2004 –Octombrie 2005

Atestation de Formation Specialisee (AFS) – CHRU “Claude Huriez” Lille, Franta (2 semestre)

28 Ianuarie 2005 10eme Seminaire de GETAID, Lille, Franta 26-30 Aprilie 2006 EASL Postgraduate Course: “Immunological phenomena in hepatitis C in and outside

of the liver”, the 41st Annual Meeting of the European Association for the Study of the Liver, Vienna, Austria

29-31 Mai 2006 Advanced Course in “Interventional GI Endoscopy Techmiques”, Strasbourg, Franta 26-27 Iunie 2006 Stagiu ESGE de Videocapsula Endoscopica, Institut « Arnault Tzanck », Saint

Laurent du Var, Franta 20-21 Mai 2006 AGA Postgraduate Course: “Recognizing and reducing risk in GI practice”, Digestive

Disease Week, Los Angeles, SUA 21 Mai 2006 SSAT (The Society for Surgery of the Alimentary Tract) Postgraduate Course, Los

Angeles, CA, SUA. 18 Septembrie - 6 Octombrie 2006

Medical University of South Carolina, Digestive Disease Center, – Capsule endoscopy training stagium, Charleston SC, SUA

11 Aprilie 2007 EASL Postgraduate Course: “The microscope at the bedside”, the 42nd Annual Meeting of the European Association for the Study of the Liver, Barcelona, Spania

23-24 Mai 2007 ASGE Postgraduate Course“Gastrointestinal Endoscopy Best Practices”, Washington DC, SUA

27-28 Octombrie 2007

Postgraduate Course: “Recent Advances in Imaging for Gastrointestinal and Liver Diseases”, 15th United European Digestive Week, Paris, France



27-28 Februarie 2008 6th IBD Intensive Advanced Course for Junior Gastroenterologists 3rd Congress of ECCO - Lyon, Franta

3-4 Aprilie 2008 EUS Diagnosis and Therapy: Expanding the Horizon, Milano, Italia 5 Aprilie 2008 Endomicroscopy – a New Dimension in 2008, Milano, Italia

23-24 Aprilie 2008 EASL Postgraduate Course: “Complications of portal hypertension”, the 43rd Annual Meeting of the European Association for the Study of the Liver, Milano, Italy

17-18 Mai 2008 Spring Postgraduate Course: Gastroenterology and Hepatology 2008: Challenges and Controversies, San Diego CA, SUA.

18 Mai 2008 SSAT Postgraduate Course: Unresolved Problems and Evolving Solutions in Surgical Gastroenterology, San Diego CA, SUA.

21-22 Mai 2008 ASGE Postgraduate Course 2008 “Endoscopic Practice 2008: At the Interface of Evidence and Expert Opinion”, DDW, San Diego CA, SUA

17 Iunie 2009 9th ECCO Educational Workshop, Cluj-Napoca, Romania 18-20 Iunie 2009 Curs precongres. Al XXIX-lea Simpozion National de Gastroenterologie, Endoscopie

Digestiva si Hepatologie, Cluj Napoca Februarie 2009-Ianuarie 2010

Medical School Hannover, Germania - Hepatic differentiation by expression of liver enriched transcription factors, Basic stem cell biology training stagium and DAAD Scholarship

21-22 Noiembrie 2009

17th UEGW Postgraduate Teaching Programme, Londra, Marea Britanie

9-10 Iunie 2010 Curs Precongres: Al XXX-lea Simpozion National de Gastroenterologie, Endoscopie Digestiva si Hepatologie, Craiova

27-30 Septembrie 2010

IASGO CME Postgraduate Course “Liver Transplantation – An interdisciplinary Approach”, Essen, Germania


Postgraduate Teaching Programme, 19th UEGW Stockholm, Suedia

24-26 Noiembrie 2011 Digestive Endoscopy Cluj 2011, Cluj-Napoca, Romania 18-19 Aprilie 2012 EASL Postgraduate Course: Parasitic, “Imported” and Alcoholic Liver Disease,

Barcelona, Spania 14 Iunie 2012 EAGEN Postgraduate Course: “Complication of Inflammation and Infection in the

Gastrointestinal Tract”, Targu Mures, Romania 20 Septembrie 2012 27th ECCO Educational Workshop: „ECCO Guidelines”, Sibiu 20 Septembrie 2012

Februarie 2013 Sesiunea de instruire si formare a medicilor implicati in derularea Programelor de Screening pentru cancerul de san, cancerul de col uterin si cancerul de colon in cadrul: Proiect POSDRU/63/3.2/S/20596 „Instruire si Preventie pentru o viata sanatoasa”

20 Mai 2013 ASGE Postgraduate Course “An International and Multidisciplinary Approach in Gastrointestinal Diseases in 2013: Patient Care at Its Best”, Chicago, IL, SUA

9-10 Aprilie 2014 EASL-IASL Postgraduate course: “Acute Liver failure/Acute on Chronic liver failure: perspective of the East and West”, Londra, UK

25-26 Aprilie 2014 Up-To-Date in Hepatology, Annual Course – “Viral Hepatitis and Liver Cirrhosis” – Current Challenges and Future Directions, Bucharest, Romania

26-28 Iunie 2014 “Scoala de vara Medicina Interna-Gastroenterologie”, Paltinis, Romania 22-23 Aprilie 2015 EASL Postgraduate course – “Metabolic liver disease”, Viena Austria

22 Aprilie 2015 EASL-ILTS-ELITA-LICAGE Post Graduate Course – “Liver Transplant”, Viena, Austria



27-28 Mai 2015 Up-To-Date in Hepatology, Annual Course – “Portal hypertension and its complications after Baveno VI Consensus Conference”; “Viral Hepatitis Anno 2015: Curring the Disease”, Bucharest, Romania

29-30 Mai 2015 EASL Monothematic Conference: “Liver Diseases in resource-limited Settings” Bucharest, Romania

11 Iunie 2015 Curs Pre-congres Gastroenterologie, Hepatologie si Endoscopie; Al XXXV-lea Congres National de Gastroenterologie, Hepatologie si Endoscopie Digestiva, Iasi 11-13 iunie 2015

22 Mai 2016 ASGE Postgraduate Course @ DDW 2016 3 Martie 2017 „Tratamente inovative in Oncologie – Analiza moleculara si terapia individualizata in

cancer”, Bucuresti 21 Octombrie 2017 Basic Science Symposium @ AASLD 2017

Premii, burse, recunoasterea

meritului stiintific

Premii Internationale (18) 18-22 Aprilie 2001 Travel Bursary Award, 36th Annual Meeting of European Association for the Study of the

Liver (EASL), Prague, Czech Republic 28 Septembrie – 3 Octombrie 2001

Travel Bursary Award, Falk Symposia No. 124-126, “Progress in Gastroenterology and Hepatology” Hannover, Germany

1-4 Noiembrie 2001

Certificate of appreciation in recognition of scientific excellence in the free paper (poster) category: Liver and Biliary Diseases

11th World Congress of the International Association of Surgeons and Gatroenterologists (IASG), Heraklion, Crete-Greece

18-21 Aprilie 2002 Travel Bursary Award – Best Eastern European Abstract, 37th Annual Meeting of European Association for the Study of the Liver (EASL), Madrid, Spain

19-22 Iunie 2002 Travel Bursary Award – Best Eastern European Abstract, 1st ESMO (European Society for Medical Oncology) Summer Educational Conference, Edinburgh, Scotland UK

19-23 June 2003 Travel Bursary Award – ESMOSummer Educational Conference, Edinburgh, UK 12-17 Octombrie

2004 Travel Bursary Award, Falk Symposia No. 142-144, “Gastroenterology Week Freiburg 2004” Freiburg, Germany

Octombrie 2005 Travel Bursary Award, Oral presentation, 13th UEGW 15-19 October 2005 Copenhagen, Danemark

23-24 Nartie 2007 Travel Bursary Award, Falk Symposium No. 158, “Intestinal Inflammation and Colorectal Cancer” Seville, Spain

17 Septembrie 2008

First prize: Falk Workshop “Strategies of Cancer Prevention in Gastroenterology”, Mainz, Germany for the paper “Early Diagnosis of small hepatocellular carcinoma in cirrhotic patients using real-time elastography”



17 Septembrie 2008

Travel Bursary Award, Falk Workshop “Strategies of Cancer Prevention in Gastroenterology”, Mainz, Germany


Travel Bursary Award, Falk Symposium no 166, “GI Endoscopy – Standards and Innovations”, Mainz, Germany


Travel Bursary Award, Falk Symposium no 167, “Liver under constant attack – from fat to viruses”, Mainz, Germany

1-5 Mai 2010 Abstract with distinction to the Digestive Disease Week 2010, New Orleans, USA for the paper: Inducible expression of Hnf4α in HUH 7,5 cell line has a strong antiproliferative effect.


Travel Bursary Award, Oral presentation, United European Gastroenterology Week 2010, Barcelona, Spain for the paper: “Hepatic differentiation of adult liver derived progenitor cells by seqeuntial expression of liver enriched transcription factors”

Octombrie 2010 UEGF/ASNEMGE National Scholar Award 2010 for the paper “Induction of liver specific genes in a fibroblast cell line by expression of liver enriched transcription factors”

6-9 Iunie 2013 APASL Liver Week Presidential Award 8-11 Iulie 2015 Travel Bursary Award: ILTS 21st Annual International Congress, Chicago, IL, USA. Premii Nationale (12) 24-27 Septembrie

2003 Premiul pentru cea mai buna lucrare prezentata in cadrul celui de-al XXIV-lea Simpozion National de Gastroenterologie, Hepatologie si Endoscopie Digestiva, Craiova 2003: “Epidemiology of inflammatory bowel disease in adult population in Romania”


Premiul Poster pentru lucrarea prezentata la cel de XXIV-lea Simpozion National de Gastroenterologie, Hepatologie si Endoscopie Digestiva, Craiova 2003:“Death predicting factors on the waiting list for liver transplantation”

1-3 Septembrie 2004

Premiul II – Postere la cel de-al XXV-lea Simpozion National de Gastroenterologie, Hepatologie si Endoscopie Digestiva, Constanta 2004, pentru lucrarea: “Efficacy of prophylactic banding ligation of high risk esophageal varices in cirrhotic patients on the waiting list for liver transplantation”

11-14 November 2004

Mentiune - Al V-lea Simpozion si Curs de Nutritie Clinica si Metabolism, Poiana Brasov, 2004

April 2008 Premiul de Excelenta al Asociatiei Medicale Romane 18-20 Iunie 2008 Premiul II al SRGH pentru lucrarea prezentata la al XXIX-lea Simpozion National de

Gastroenterologie, Hepatologie si Endoscopie Digestiva, Cluj-Napoca 2009: “ ASCA and ANCA serology in Romanian IBD Patients”.

27-28 November 2008

Premiul I – Postere. Sesiunea Stiintifica a Institutului Clinic Fundeni si a Institutului de Boli Cardiovasculare Prof. Dr. C. C. Iliescu: “Investigarea profilului de expresie a genelor implicate in medierea reactiilor inflamatorii la pacientii cu IBD utilizand tehnica MLPA”

15-16 Aprilie 2010 Premiul de Excelenta pentru lucrarea prezentata in cadrul celui de-al V-lea Simpozion “Acad. Nicolae Cajal: “Generation of hepatocyte-like cells from stem cell sources”

19-21 Mai 2011 Premiul III al SRGH pentru lucrarea: “Poate fi utilizat polimorfismul genei IL28B pentru predictia raspunsului virusologic precoce la pacienti cu hepatita recurenta post transplant Hepatic?” Al XXXI-lea Simpozion National de Gastroenterologie, Hepatologie si Endoscopie Digestiva

12-15 Iunie 2013 Premiul I al Societatii Romane de Gastroenterologie pentru lucrarea prezentata in cadrul celui de-al XXXIII-lea Congres National de Gastroenterologie, Hepatologie si Endoscopie Digestiva, Timisoara 2013: “Expresia genica cantitativa a factorilor de transcriptie hepatici poate fi utilizata pentru predictia recurentei tumorale la pacientii cu hepatocarcinom tratati cu viza curativa”



ACTIVITATEA DE CERCETARE STIINTIFICA: PROIECTE DE CERCETARE-

DEZVOLTARE-INOVARE

OBTINUTE PRIN COMPETITIE PE

BAZA DE CONTRACT/GRANT

TITLU (ACRONIM) Perioada Functie

Grant/Proiect National

1.

Proiect VIASAN 324/2004. „Rolul evidentei computerizate a pacientilor in identificarea potentialilor candidati pentru transplantul hepatic si in urmarirea dinamicii listei de asteptare” (HEPASIST). Buget: 920000000 ROL

2004-2006 Cercetator

2.

Proiect VIASAN 322/2004. „Rolul manometriei esofagiene in diagnosticul achalasiei la pacientii cu disfagie si in evaluarea eficientei tratamentului endoscopic sau chirurgical al afectiunii” (ROMAC). Buget: 1265000000 ROL


3.

Proiect VIASAN 428/2004. „Evidenta computerizata prospectiva a pacientilor cu risc pentru dezvoltarea cancerului colorectal la care se impune screeningul si supravegherea” (COLOCANS). Buget: 920000000 ROL


4. Proiect CEEX 142/2006. „Diagnosticul non-invaziv si markeri de prognostic ai hepatocarcinomului detectat in leziunile focale


12-14 Iunie 2014 Premiul SRGH pentru cea mai buna prezentare orala: „Profilul de expresie genica al genelor specifice celulelor stem/progenitoare hepatice in hepatocarcinom si semnificatiile prognostice”.

1-4 Aprilie 2015 Premiul „Herbert Beller Barbu” pentru tineri cercetatori pentru lucrarea prezentata in cadrul celui de-al X-lea Simpozion „Acad. Nicolae Cajal”: “Deletia rs199508964 din exonul 6 al genei IRF5 se coreleaza cu polimorfismul genei Il28B rs12980275 si prezice raspunsul virusologic sustinut la pacientii cu hepatita recurenta C post-transplant hepatic”.



nodulare din ciroza hepatica” (PROSONOHEP). Buget: 1500000 RON

5.

Proiect CEEX 89/2006. „Implicaţii diagnostice şi prognostice ale aspectului endomicroscopic al microvascularizaţiei leziunilor premaligne şi maligne ale tubului digestiv superior” (DIAPROGENDO). Buget: 1500000 RON


6.

Proiect CEEX 60/2006. „Evaluarea fenotipica si genotipica a pacientilor cu boli inflamatorii intestinale cronice din Romania si generarea unui registru biregional computerizat de urmarire prospectiva” (IBDPROSPECT). Buget: 1500000 RON


7. Proiect CEEX 65/2006. „Potenţialul Terapeutic al Celulelor Stem Hematopoietice în Afecţiunile Hepatice” (LIVERSTEM). Buget 1500000 RON


8.

Proiect PNII 41073/2007. „Acuratetea diagnostica a videocapsulei endoscopice comparativ cu enteroscopia cu balon in patologia intestinului subtire” (ENTERODIAG). Buget Partener 2: 456710 RON

2007-2010

Cercetator Partener 2 (UMFCarol Davila)

9.

Proiect PNII 42170/2008 ENDONERD „Valoarea endomicroscopiei confocale laser si a endoscopiei cu magnificatie, in banda ingusta (NBI), in diagnosticul bolii de reflux gastroesofagian nonerozive”. Buget: 1521600 RON


10.

Proiect PNII 42169/2008 GENOWIL „Valoarea diagnostica si prognostica a analizei genetice si corelatii genotip-fenotip la pacientii cu boala Wilson”. Buget: 1963000 RON


11.

Proiect PNII 42162/2008 ”Factori predictivi ai raspunsului serologic, imagistic, imunohistochimic si histologic hepatic la pacientii cu obezitate morbida si ficat gras nonalcoolic supusi chirurgiei bariatrice” (BAROFAT). Buget: 1850000 RON


12.

Proiect PNII-PD23/2011. ”Evaluarea cantitativa a expresiei factorilor de transcriptie hepatici in hepatocarcinom – noi marker de prognostic pentru recurenta tumorii dupa tratamentul curativ”. Buget 300000 RON.

2011-2013

Director Proiect

13.

Proiect PNII- PCE 125/2011. Molecular predictors of prognosis following curative treatment of hepatocellular carcinoma – the significance of liver stem/progenitor cells genes, Buget: 1437500 RON




14.

Proiect finantat prin programul „Cercetare in domenii prioritare”, mecanismul financiar al Spatiului Economic European (SEE). EEA-JRP Romania-Norvegia Nr proiect 4SEE. Stratificarea pacientilor cu carcinom hepatocelular prin identificarea unor markeri neinvazivi. Buget: 1125000Eur, Co-finantare privata: 180916 EUR


Studii multicentrice internationale

1

“Healing of patients suffering from gastroesophageal reflux esophagitis grade C-D according to Los Angeles classification after treatment with pantoprazole-magnesium dihydrate 80 mg o.d. in comparison to pantoprazole - sodium sesquihydrate 40 mg o.d. over 4 or 8 weeks” Magnum 2. Protocol BY1023/M3-904

2004 Co-investigator

Principalele rezultate obtinute ca membru al echipei de cercetare a proiectelor: VIASAN 324/2004: Hepasist Gheorghe L, Popescu I, Iacob R, Iacob S, Gheorghe C. Predictors of death on the waiting list for liver transplantation characterized by a long waiting time. Transpl Int. 2005 May;18(5):572-6. Gheorghe L, Iacob S, Simionov I, Vadan R, Gheorghe C, Iacob R, Parvulescu I, Constantinescu I. Natural history of compensated viral B and D cirrhosis. Rom J Gastroenterol. 2005 Dec;14(4):329-35. S. Iacob, L. Gheorghe, R. Iacob, C. Gheorghe, D. Bucur, A. Croitoru, I. Popescu. Predictive factors for the development of hepatocellular carcinoma in cirrhotic patients. 14th World Congress of the International Association of Surgeons and Gastroenterologists (IASG), Zurich, Switzerland, 9-12 September 2004. Prezentare orala Proiect VIASAN 322/2004: Romac Gheorghe C, Bancila I, Tutuian R, Iacob R, Tomulescu V. Predictors of short term treatment outcome in patients with achalasia following endoscopic or surgical therapy. Hepatogastroenterology. 2012 Nov-Dec;59(120):2503-7. R. Iacob, J. Quinton, F. Guillemot, F. Pattou, I. Bancila, C. Gheorghe, S. Iacob, L. Gheorghe, M. Diculescu. Esophageal manometry abnormalities after gastric banding for morbid obesity. 13th United European Gastroenterology Week (UEGW), Copenhagen, Denmark, 15-19 October 2005. Prezentare orala Proiect VIASAN 428/2004: Colocans Iacob R, Iacob S, Gheorghe L, Gheorghe C, Diculescu M. The use of IT in the medical system has economic and research advantages--the experience of Fundeni Gastroenterology and Hepatology Center. Rom J Gastroenterol. 2005 Dec;14(4):426-9. Gheorghe C, Iacob R, Gheorghe L, Cotruta B, Bancila I, Iacob S, Bucur D, Voinea D, Popescu I. Projected Dynamics of Colonoscopic Screening and Surveillance for Colorectal Cancer. Hepato-Gastroenterology 2008; 55:1568-1572 R. Iacob, I. Vartan, L. Gheorghe, B. Cotruta, S. Iacob, L. Tugui, I. Bancila, M. Ionescu, I. Popescu, C. Gheorghe. Familial polyposis syndromes registry – screening, diagnosis, tratment and follow-up. 17th World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists, 5-8 September 2007, Bucharest,



Romania. Prezentare orala. Proiect CEEX 142/2006: Prosonohep Gheorghe L, Iacob S, Iacob R, Gheorghe C, Popescu I. Variation of the MELD score as a predictor of death on the waiting list for liver transplantation. J Gastrointestin Liver Dis 2007; 16(3):267-272 Gheorghe L, Iacob S, Iacob R, Dumbrava M, Becheanu G, Herlea V, Gheorghe C, Lupescu I, Popescu I. Real Time Elastography – a noninvasive diagnostic method of small hepatocellular carcinoma in cirrhosis. J Gastrointestin Liver Dis 2009;18 (4):439-446 Premiul I: Falk Workshop “Strategies of Cancer Prevention in Gastroenterology”, Mainz, Germany for the paper “Early Diagnosis of small hepatocellular carcinoma in cirrhotic patients using real-time elastography”. 17 Septembrie 2008 Gheorghe L, Iacob S, Iacob R, Becheanu G, Dumbrava M. Real – time elastography – a novel approach to assess liver fibrosis in patients with chronic hepatitis C. 18th World Congress of the International Association of Surgeons, gastroenterologists and Oncologists, 8-11 October 2008, Istanbul, Turkey. Prezentare orala. Proiect CEEX 89/2006: Diaprogendo Gheorghe C, Dumbrava M, Iacob R, Gheorghe L, Herlea V, Ionescu M. Endomicroscopy and ecoendoscopy in the same session for the diagnosis of early gastric cancer. Archives of the Balkan Medical Union 2007; 42: 69-70 Gheorghe C, Iacob R, Becheanu G, Dumbrava M. Confocal endomicroscopy for in vivo microscopic analysis of upper gastrointestinal tract premalignant and malignant lesions. J Gastrointestin Liver Dis. 2008 Mar;17(1):95-100 Gheorghe C, Iacob R, Dumbrava M, Becheanu G, Ionescu M. Confocal laser endomicroscopy and ultrasound endoscopy during the same endoscopic session for diagnosis and staging of gastric neoplastic lesions. Chirurgia (Bucur). 2009 Jan-Feb;104(1):17-24. Proiect CEEX 60/2006: IBDPROSPECT Gologan S, Iacob R, Preda C, Vadan R, Cotruta B, Catuneanu AM, Iacob S, Constantinescu I, Gheorghe L, Iobagiu S, Gheorghe C, Diculescu M. Higher Titers of Anti–Saccharomyces Cerevisiae AntibodiesIgA and IgG are Associated with More Aggressive Phenotypes in Romanian Patients with Crohn’s Disease. J Gastrointestin Liver Dis. 2012 Mar;21(1):39-44. Gologan S, Iacob R, Iancu D, Iacob S, Cotruta B, Vadan R, Catuneanu AM, Constantinescu I, Barbarii L, Gheorghe C, Diculescu M. Inflammatory gene expression profiles in Crohn's disease and ulcerative colitis: a comparative analysis using a reverse transcriptase multiplex ligation-dependent probe amplification protocol. J Crohns Colitis. 2013 Sep;7(8):622-30. Zaharie R, Tantau A, Zaharie F, Tantau M, Gheorghe L, Gheorghe C, Gologan S, Cijevschi C, Trifan A, Dobru D, Goldis A, Constantinescu G, Iacob R, Diculescu M; IBDPROSPECT Study Group. Diagnostic Delay in Romanian Patients with Inflammatory Bowel Disease: Risk Factors and Impact on the Disease Course and Need for Surgery. J Crohns Colitis. 2015 Nov 20. pii: jjv215. [Epub ahead of print] Premiul al-II-lea al SRGH pentru lucrarea prezentata la al XXIX-lea Simpozion National de Gastroenterologie, Hepatologie si Endoscopie Digestiva, Cluj-Napoca 2009: “ ASCA and ANCA serology in Romanian IBD Patients”. Iunie 2008. Premiul I – Postere. Sesiunea Stiintifica a Institutului Clinic Fundeni si a Institutului de Boli Cardiovasculare Prof. Dr. C. C. Iliescu: Investigarea profilului de expresie a genelor implicate in medierea reactiilor inflamatorii la pacientii cu IBD utilizand tehnica MLPA. Noiembrie 2008 R Iacob. Colombel JF. Nouvelle clasification phenotypique des MICI. 30eme Edition Les Journees Francophones de Pathologie Digestive. Paris, France 18-22 Mars 2006. Prezentare orala, speaker invitat. Iacob R. Forum Y-ECCO. The IVth National Symposium of Inflammatory Bowel Diseases. 21-22 September 2012, Sibiu, Romania. Chairman masa rotunda.



Diculescu M, Iacob R. IBDProspect, where are we in 2012. The IVth National Symposium of Inflammatory Bowel Diseases. 21-22 September 2012, Sibiu, Romania. Prezentare orala Proiect CEEX 65/2006: LIVERSTEM Iacob R, Sirbu-Boeti P, Iacob S, Dima S, Gheorghe C, Gheorghe L; Popescu I. Stem cell therapies for gastrointestinal and liver diseases. Chirurgia (Bucur) 2009;104: 131-140. Iacob R. Dima S, Popescu I. Transplantul de celule stem, controversa etica sau terapia viitorului in afectiunile hepatice cronice? In Excelenta medicala in vremea crizei. Sub Red. Mihailide M. Bucuresti: Viata Medicala Romaneasca 2010: 143-150. ISBN 978-973-160-044-4 Proiect PNII 41073/2007: Enterodiag Gheorghe C, Iacob R, Bancila I, Herlea V, Hrehoret D. Ampullary bleeding diagnosed using CCD high resolution and real time viewer capsule endoscope system. J Gastrointestin Liver Dis 2007. Jun;16(2):187-210. Gheorghe C, Iacob R, Bancila I. Olympus capsule endoscopy for small bowel examination. J Gastrointestin Liver Dis 2007. Sep;16(3):309-13. Proiect PNII 42170/2008 : Endonerd Bancila I, Cotruta B, Iacob R, Gheorghe C. Corelatii intre datele de impedanta-pH-metrie si aspectul endomicroscopic esofagian in boala de reflux non-eroziva. In Actualitati in gastroenterology: patologie functionala de moitilitate si inflamatorie. Sub Redactia Dumitrascu DL, Drug VL, Surdea Blaga T. Editura Medicala Universitara “Iuliu Hatieganu” 2014. Cluj-Napoca. 13-18. ISBN 978-973-693-562-6 Gheorghe C, Cotruta B, Iacob R, Bancila I, Becheanu G. Magnification endoscopy with narrow band imaging for diagnosis of the equivocal gastric lesions. Archives of the Balkan Medical Union 2008; 43: 286-288 Proiect PNII 42169/2008: Genowil Iacob S, Gheorghe L, Iacob R, Gheorghe C, Hrehoret D, Popescu I. MELD exceptions and new predictive score of death on long waiting lists for liver transplantation. Chirurgia (Bucur) 2009;104: 267-273 Iacob R, Iacob S, Nastase A, Vagu C, Ene AM, Constantinescu A, Anghel D, Banica C, Paslaru L, Coriu D, Dima S, Gheorghe C, Ionica E, Gheorghe L. The His1069Gln mutation in the ATP7B gene in Romanian patients with Wilson's disease referred to a tertiary gastroenterology center. J Gastrointestin Liver Dis. 2012 Jun;21(2):181-5. Iacob R, Iacob S, Nastase A, Vagu C, Ene AM, Constantinescu A, Anghel D, Banica C, Paslaru L, Coriu D, Dima S, Ionica E, Gheorghe L. The His1069Gln mutation in the ATP7B gene, in Romanian patients with Wilson’s Disease, referred to a tertiary gastroenterology Center. VIIth “Academician Nicolae Cajal” Symposium. 28-31 March 2012, Bucharest, Romania. Prezentare orala. Proiect 42162/2008: Barofat Gheorghe C, Pascu O, Iacob R, Vadan R, Iacob S, Goldis A, Tantau M, Dumitru E, Dobru D, Miutescu E, Saftoiu A, Fraticiu A, Tomescu D, Gheorghe L. Nutritional risk screening and prevalence of malnutrition on admission to gastroenterology departments: a multicentric study. Chirurgia (Bucur). 2013 Jul-Aug;108(4):535-41. Proiect PNII 125/2011 Gheorghe L, Iacob S, Iacob R, Smira G, Pietrareanu C, Hrehoret D, Brasoveanu V, Gheorghe C, Popescu I. Dynamics of the Romanian waiting list for liver transplantation after changing organ allocation policy. J Gastrointestin Liver Dis. 2013 Sep;22(3):299-303. Iacob S, Gheorghe L, Tabacelia D, Iacob R, Gheorghe C, Popescu I. A new score to predict outcome after liver transplantation. J. Transl. Med. Res 2015;20(3):123-131 Iacob R, Herlea V, Popa C, Nastase A, Ghetea L, Iacob S, Botea F, Pechianu C, Grigorie R, Croitoru A, Dima S, Gheorghe C, Gheorghe L, Popescu I. Prognostic significance of CD44 expression in hepatocellular carcinoma following a potentially curative treatment. J Transl Med Res 2016; 21 (4): 267-273.



APASL Liver Week Presidential Award. Iunie 2013 Premiul SRGH pentru cea mai buna prezentare orala: „Profilul de expresie genica al genelor specifice celulelor stem/progenitoare hepatice in hepatocarcinom si semnificatiile prognostice”. Iunie 2014. S. Iacob, R. Iacob, C. Gheorghe, L. Gheorghe, I. Popescu. New organ allocation score predicting both pre and post-transplant survival in the Romanian National Transplant Program. ESOT- 17th Congress of the European Society for Organ Transplantation, Bruxelles, Belgia, 13-16 September 2015. Prezentare orala. Proiect PNII-PD 23/2011 Iacob R, Iacob S, Gheorghe L, Gheorghe C, Hrehoreţ D, Brașoveanu V, Croitoru A, Herlea V, Popescu I. Outcome of liver transplantation for hepatocellular carcinoma -- a single center experience. Chirurgia (Bucur). 2013 Jul-Aug;108(4):446-50. Abstract with distinction to the Digestive Disease Week 2010, New Orleans, USA pentru lucrarea: “Inducible expression of Hnf4α in HUH 7,5 cell line has a strong antiproliferative effect”. Mai 2010 UEGF/ASNEMGE National Scholar Award 2010 pentru lucrarea “Induction of liver specific genes in a fibroblast cell line by expression of liver enriched transcription factors” Premiul I al Societatii Romane de Gastroenterologie pentru lucrarea prezentata in cadrul celui de-al XXXIII-lea Congres National de Gastroenterologie, Hepatologie si Endoscopie Digestiva, Timisoara 2013: “Expresia genica cantitativa a factorilor de transcriptie hepatici poate fi utilizata pentru predictia recurentei tumorale la pacientii cu hepatocarcinom tratati cu viza curativa. Iunie 2013”. Iacob R, Iacob S, Nastase A, Ilie V, Sorop A, Florea R, Herlea V, Croitoru A, Dima S, Gheorghe C, Gheorghe L, Ott M, Popescu I. Prognostic and therapeutic significance of HNF4alpha expression in hepatocellular carcinoma. Xth “Academician Nicolae Cajal” Symposium. 1-4 April 2015, Bucharest, Romania. Prezentare orala EEA-JRP Romania-Norvegia Nr proiect 4SEE/2014. R. Florea, VM Ilie, A. Sorop, V. Tica, L.L. Paslaru, N. Bacalbasa, R. Iacob, S. Dima, I. Popescu. Citostatic dose dependent EMT transition as a result of FoxC1 overexpression in human hepatocellular carcinoma cell lines. Transl Med Res 2015, 20(Suppl II). R. Iacob, C. Vagu, A. Nastase, S. Iacob, F. Botea, R. Grigorie, L. Stoica, V. Herlea, A. Croitoru, S. Dima, L. Gheorghe, C. Gheorghe, M. Ott, I. Popescu. Significance of Liver Enriched Transcription Factors as Molecular Markers for Hepatocellular Carcinoma Recurrence After a Potentially Curative Treatment. Transplantation 2015, 99(Suppl 7S); 224. ILTS 21st Annual International Congress, Chicago, IL, USA, July 8-11 2015. Poster.

PUBLICATII Articole originale publicate in extenso in reviste indexate ISI: 38 Articole originale publicate in extenso in reviste indexate BDI: 17 Articole si lucrari cu caracter educational: 6 Capitole de carte publicate: 8 Prezentari orale - speaker invitat: 10 Prezentari orale la manifestari stiintifice internationale: 8 Prezentari orale la manifestari stiintifice nationale: 58 Rezumate publicate in reviste indexate ISI: 180



Rezumate publicate in volumele unor manifestari stiintifice cu ISBN/ISSN: 74 Lucrari prezentate sub forma de poster la manifestari stiintifice internationale si nationale: 269 Indice Hirsch Google Scholar (8.1.2018): 20 Indice Hirsch ISI Web of Science (8.1.2018): 13 I-10 Index Google Scholar (8.1.2018): 31 Numar citari Google Scholar (8.1.2018): 1005 Nr Citari ISI Web of Science (8.1.2018): 393

Data: 08.01.2018

Iacob Razvan Andrei

informaŢii iacob razvan andrei personale€¦ · 2002 diploma de licenta: 430/ 13.03.2002 seria t...

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