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ZILELE MEDICAMENTULUI
EDITIA A XX a
IASI
19 -20 MAI 2011
VICTOR COJOCARU
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STUPOARE, CONSTERNARE, REVOLTA,
ANXIETATE, DEPRESIE, FRUSTRARE,
RESEMNARE
Durerea apare odata cu primele vietati dotate cusisteme nervoase integrate si nu pare ca se va sfarsidecat odata cu disparitia omului.
Experienta durerii se inregistreaza si in timpul starilorinconstiente dar greveaza mai ales experientaconstienta, sculptandnoua viata a omului ganditor.
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RETEAUA CEREBRALA A DURERII
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A. Vania Apkarian, Yamaya Sosa, Sreepadma Sonty, Robert M. Levy, R.
Norman Harden, Todd B. Parrish, Darren R. Gitelman - Chronic Back
Pain Is Associated with Decreased Prefrontal and Thalamic Gray Matter
Density, The Journal of Neuroscience, Nov. 17, 2004 . 4(46):1041010415
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Baliki MN, Chiavlo DR, Geha PY, Levy RM, Harden RN,Parrish TB, Apkarian
AV- Chronic Pain and the Emotional Brain: Specific Brain Activity Associated with
Spontaneous Fluctuations of Intensity of Chronic Back Pain, The Journal of
Neuroscience, Nov 22, 2006, 26(47): 12165-12173.
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Baltki MN, Geha PY, Apkarian AV, Chialvo DRBeyond Feeling Chronic Pain
Hurts the Brain, Disrupting the Default-Mode Network Dynamics The Journa
of Neuroscience, Feb 2008, 28(6):13981403
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EXTENSIA AFECTIVA A DURERII
(Form.Reticulat, N
parabrahial,
Amigdala, Aria
sup. motorie,
Hipotalamus)
SEMNALNOCICEPTIV
(Spino-talamic, Spino-reticulat, Cordonul dorsal)
(Spino-ponto-amigdalian,Spino-hipotalamic)
SENZAIANOCICEPTIV
(S1, S2, Anterior insula, Cingulat posterior)DECLANAREAACTIVRII
VEGETATIVE/SOMATOMOTORII
EVALURI ISEMNIFICAII
COGNITIVE1) AGRESIUNE
2) AMENINARE
(7b, Cortex parietal post., Cortex
cingulat anterior)
FAZA 1AFECT
EXPRESIADURERII
(Sistemul somatomotor
i cel
vegetativ)1) BLOCARE2) DIFICULTATE3) NGRIJORARE
PENTRUVIITOR
(Arii corticale
prefrontale) FAZA 2
AFECT
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Bastian B, Jetten J, Fasoli FV -Cleansing the Soul by Hurting the Flesh:
The Guilt-Reducing Effect of Pain. Psychological Science, March 2011; vol.
22, 3: pp. 334-335.
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Eisenberg DP, Kohn PD, Baller EB, Bronstein JA, et al
Seasonal Effects on Human Striatal Presynaptic Dopamine Synthesis, J
Neurosci2010, 30(44):14691-4.
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Marjolein P.M. Kammers, Frdrique de Vignemont, Patrick Haggard
- Cooling the Thermal Grill Illusion through Self-Touch, Current Biology,
Vol 20(20) 26 October 2010, 1819-1822.
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Rainville P, Duncan GH, Price DD, Carrier B, M. Catherine Bushnell
Bushnell MC - Pain Affect Encoded in Human Anterior Cingulate But Not
Somatosensory Cortex, Scienc e 1997:
Vol. 277 no . 5328 pp . 968-971
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Ploghaus A, Charvy N ,Beckmann CF et al, Exacerbation of Pain by
Anxiety Is Associated with Activity in a Hippocampal Network
, The Journal of Neuroscience, 15 December 2001, 21(24): 9896-9903
Ploghaus A, Charvy N ,Beckmann CF et al, Exacerbation of Pain by
Anxiety Is Associated with Activity in a Hippocampal Network
, The Journal of Neuroscience, 15 December 2001, 21(24): 9896-9903
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DeWall CN, Macdonald G, Webster GD et al -Acetaminophen reduces
social pain: behavioral and neural evidence, Psychol Sci. 2010
Jul;21(7):931-7