cojocaru zm 2011 interfata durerii

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  • 7/29/2019 Cojocaru ZM 2011 Interfata Durerii

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    ZILELE MEDICAMENTULUI

    EDITIA A XX a

    IASI

    19 -20 MAI 2011

    VICTOR COJOCARU

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    STUPOARE, CONSTERNARE, REVOLTA,

    ANXIETATE, DEPRESIE, FRUSTRARE,

    RESEMNARE

    Durerea apare odata cu primele vietati dotate cusisteme nervoase integrate si nu pare ca se va sfarsidecat odata cu disparitia omului.

    Experienta durerii se inregistreaza si in timpul starilorinconstiente dar greveaza mai ales experientaconstienta, sculptandnoua viata a omului ganditor.

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    RETEAUA CEREBRALA A DURERII

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    A. Vania Apkarian, Yamaya Sosa, Sreepadma Sonty, Robert M. Levy, R.

    Norman Harden, Todd B. Parrish, Darren R. Gitelman - Chronic Back

    Pain Is Associated with Decreased Prefrontal and Thalamic Gray Matter

    Density, The Journal of Neuroscience, Nov. 17, 2004 . 4(46):1041010415

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    Baliki MN, Chiavlo DR, Geha PY, Levy RM, Harden RN,Parrish TB, Apkarian

    AV- Chronic Pain and the Emotional Brain: Specific Brain Activity Associated with

    Spontaneous Fluctuations of Intensity of Chronic Back Pain, The Journal of

    Neuroscience, Nov 22, 2006, 26(47): 12165-12173.

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    Baltki MN, Geha PY, Apkarian AV, Chialvo DRBeyond Feeling Chronic Pain

    Hurts the Brain, Disrupting the Default-Mode Network Dynamics The Journa

    of Neuroscience, Feb 2008, 28(6):13981403

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    EXTENSIA AFECTIVA A DURERII

    (Form.Reticulat, N

    parabrahial,

    Amigdala, Aria

    sup. motorie,

    Hipotalamus)

    SEMNALNOCICEPTIV

    (Spino-talamic, Spino-reticulat, Cordonul dorsal)

    (Spino-ponto-amigdalian,Spino-hipotalamic)

    SENZAIANOCICEPTIV

    (S1, S2, Anterior insula, Cingulat posterior)DECLANAREAACTIVRII

    VEGETATIVE/SOMATOMOTORII

    EVALURI ISEMNIFICAII

    COGNITIVE1) AGRESIUNE

    2) AMENINARE

    (7b, Cortex parietal post., Cortex

    cingulat anterior)

    FAZA 1AFECT

    EXPRESIADURERII

    (Sistemul somatomotor

    i cel

    vegetativ)1) BLOCARE2) DIFICULTATE3) NGRIJORARE

    PENTRUVIITOR

    (Arii corticale

    prefrontale) FAZA 2

    AFECT

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    Bastian B, Jetten J, Fasoli FV -Cleansing the Soul by Hurting the Flesh:

    The Guilt-Reducing Effect of Pain. Psychological Science, March 2011; vol.

    22, 3: pp. 334-335.

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    Eisenberg DP, Kohn PD, Baller EB, Bronstein JA, et al

    Seasonal Effects on Human Striatal Presynaptic Dopamine Synthesis, J

    Neurosci2010, 30(44):14691-4.

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    Marjolein P.M. Kammers, Frdrique de Vignemont, Patrick Haggard

    - Cooling the Thermal Grill Illusion through Self-Touch, Current Biology,

    Vol 20(20) 26 October 2010, 1819-1822.

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    Rainville P, Duncan GH, Price DD, Carrier B, M. Catherine Bushnell

    Bushnell MC - Pain Affect Encoded in Human Anterior Cingulate But Not

    Somatosensory Cortex, Scienc e 1997:

    Vol. 277 no . 5328 pp . 968-971

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    Ploghaus A, Charvy N ,Beckmann CF et al, Exacerbation of Pain by

    Anxiety Is Associated with Activity in a Hippocampal Network

    , The Journal of Neuroscience, 15 December 2001, 21(24): 9896-9903

    Ploghaus A, Charvy N ,Beckmann CF et al, Exacerbation of Pain by

    Anxiety Is Associated with Activity in a Hippocampal Network

    , The Journal of Neuroscience, 15 December 2001, 21(24): 9896-9903

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    DeWall CN, Macdonald G, Webster GD et al -Acetaminophen reduces

    social pain: behavioral and neural evidence, Psychol Sci. 2010

    Jul;21(7):931-7