curs 13-14
Post on 08-Nov-2014
179 Views
Preview:
DESCRIPTION
TRANSCRIPT
PENICILINE DE SEMISINTEZĂ
Peniciline stabile în mediu acid
FENETICILINA
PHENETHYCILLINUM (DCI)
N
SCH3
CH3
COOH
NHC
O
CH
O
O
CH3
Acid (2S, 5R, 6R)-3,3-dimetil-7-oxo-6-(fenoxipropionamido)-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
((1-Fenoxietil)-penicilina sau (-fenoxietil)-penicilina)
• Sinonime: Penicilina B; Penicilina MV.
Feneticilina
N
SCH3
CH3
COOH
NHC
O
CH
O
O
CH3
Clorura aciduluialfa-fenoxipropionic
+NH(C2H5)3Cl
--
N(C2H5)3O CH C
O
ClCH3
+
6-APA
C
N CH
CS
C
C
CH3
CH3
COOHO
H2NH H
PF: BROXIL (SmithKline Beecham, Olanda) – capsule a 500 mg feneticilina potasica.
PROPICILINAPROPICILLINUM (DCI)
N
SCH3
CH3
COOH
NHC
O
CH
O
O
CH2
CH3
Acid (2S, 5R, 6R)-3,3-dimetil-7-oxo-6-(2-fenoxibutiramido)-4-tia-1-azabiciclo 3. 2. 0
heptan-2-carboxilic(1-Fenoxipropil-penicilina sau -Fenoxipropil-penicilina)
• Sinonim: Fenoxipropilpenicilina.
Propicilina
N
SCH3
CH3
COOH
NHC
O
CH
O
O
CH2
CH3
Clorura aciduluialfa-fenoxibutiric
+NH(C2H5)3Cl
--
N(C2H5)3O CH C
O
ClC2H5
+
6-APA
C
N CH
CS
C
C
CH3
CH3
COOHO
H2NH H
• PF: BAYCILLIN MEGA (Bayer Vital, Germania) – comprimate filmate a 1 mil. UI / cp.
FENBENICILINAPHENBENICILLINUM (DCI)
N
SCH3
CH3
COOH
NHC
O
CH
O
O
Acid (2S, 5R, 6R)-3,3-dimetil-7-oxo-6-(2-fenoxi-2-fenilacetamido)-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
(-fenoxibenzilpenicilina)
Fenbenicilina
N
SCH3
CH3
COOH
NHC
O
CH
O
O
Clorura aciduluialfa-fenoxifenilacetic
+NH(C2H5)3Cl--
N(C2H5)3O CH C
O
ClC6H5
+
6-APA
C
N CH
CS
C
C
CH3
CH3
COOHO
H2NH H
AZIDOCILINAAZIDOCILLINUM (DCI)
N
S
COOH
CH3
CH3
O
NHC
O
N3
Acid (2S, 5R, 6R)-6-(R)-2-azido-2-fenilacetamido- 3,3-dimetil-7-oxo 4-tia-1-azabiciclo
3. 2. 0 heptan-2-carboxilic
• PF: LONGATREN (Bayer, Austria) – comprimate a 750 mg azidocilin\ / cp.
CLOMETOCILINACLOMETOCILLINUM (DCI)
N
SCH3
CH3
COOH
NHC
O
CH
OOCH3
Cl
ClAcid (2S, 5R, 6R)-3,3-dimetil-7-oxo-6-2-(3, 4-diclorofenil)-2-metoxi-acetamido-4-
tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic(3,4-diclor--metoxibenzilpenicilina)
• Sinonim: Penicilina 356.
• PF: RIXAPEN (Menarini, Belgia) – comprimate a 500 mg
Peniciline rezistente la penicilinaza stafilococică
Peniciline rezistente la penicilinază şi instabile la aciditatea gastrică
METICILINA SODIC|METHICILLINUM NATRICUM (DCI)
N
SCH3
CH3
COO-
NHC
O
O
OCH3
OCH3
Na+ . H2O
Sarea de sodiu a acidului (2S, 5R, 6R)-6-(2,6-dimetoxibenzamido)- 3,3-dimetil-7-oxo 4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
• Sinonim: Dimetoxifenecilina.
Clorura acidului2,6-dimetoxibenzoic
+NH(C2H5)3Cl
--
N(C2H5)3
OCH3
OCH3
+
6-APA
C
N CH
CS
C
C
CH3
CH3
COOHO
H2NH H
CO
Cl
N
SCH3
CH3
COOH
NHC
O
O
OCH3
OCH3
Meticilina
• PF: STAFICYN (Firma, Italia) – flacoane cu pulbere injectabilă (1 g meticilină sodică)
Peniciline cu structură izoxazolică
Peniciline rezistente la penicilinază şi stabile la aciditatea gastrică
OXACILINA SODIC|OXACILLINUM NATRICUM (DCI, FR X)
N
SCH3
CH3
COO-
NHC
O
ON
O CH3
Na+ . H2O
Sarea de sodiu a acidului (2S, 5R, 6R)-3,3-dimetil-6-(5-metil-3-fenil-4-izoxazolcarboxamido)-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
• Sinonim: Oxazocilina.
Clorura acidului3-fenil-5-metil-izoxazolil-4-carboxilic
+NH(C2H5)3Cl
--
N(C2H5)3+
6-APA
C
N CH
CS
C
C
CH3
CH3
COOHO
H2NH H
N
SCH3
CH3
COOH
NHC
O
ON
O CH3
NO CH3
Cl
OC
Oxacilina
• PF: OXACILINA (Antibiotice S.A.; Europharm; Lek Pharmatech, România) – capsule 250 mg
oxacilina sodica / cps; pulbere pentru solutie injectabila (250 mg, 500 mg sau 1 g oxacilina sodica).
BACTOCILL (SmithKline Beecham, SUA) - pulbere pentru solutie injectabila - 1 g şi 2 g
oxacilina sodica.
STAPENOR (Bayer, Austria) - pulbere pentru solutie injectabila - 1 g oxacilina sodica.
CLOXACILINA SODIC|CLOXACILLINUM NATRICUM (DCI)
N
SCH3
CH3
COOH
NHC
O
ON
O CH3Cl
Na+ . H2O
Sarea de sodiu a acidului (2S, 5R, 6R)-6-3-(o-clorofenil)-5-metil-4-izoxazolcarboxamido)- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-
carboxilic
Clorura acidului3-o-clorofenil-5-metil-izoxazolil-4-carboxilic
+NH(C2H5)3Cl
--
N(C2H5)3
Cl
+
6-APA
C
N CH
CS
C
C
CH3
CH3
COOHO
H2NH H
N
SCH3
CH3
COOH
NHC
O
ON
O CH3Cl
NO CH3
Cl
OC
Cloxacilina
Na+ . H2O
• PF. ORBENIN (SmithKline Beecham, Australia; Singapore; Africa de Sud;
Irlanda) – capsule 250 [i 500 mg ; sirop 125 mg / 5 ml; pulbere pentru solu]ie
injectabil\ (250 mg [i 500 mg);
AMPICLOX (Europharm SA, România) – capsule con]inând cloxacilin\
sodic\ (echivalentul a 250 mg cloxacilin\) [i ampicilin\ trihidrat (echivalentul a
250 mg ampicilin\ anhidr\).
DICLOXACILINA SODIC|DICLOXACILLINUM NATRICUM (DCI)
N
SCH3
CH3
COOH
NHC
O
ON
O CH3Cl
Cl
Na+ . H2O
Sarea de sodiu a acidului (2S, 5R, 6R)-6-3-(2,6-diclorofenil)-5-metil-4-izoxazolcarboxamido)- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0
heptan-2-carboxilic
• PF: DICLOCIL (Bristol-Myers Squibb) - capsule 250 şi 500 mg ; pulbere pentru solutie injectabila (500 mg şi 1000 mg);
DYNAPEN (Apothecon, SUA) - capsule 250 şi 500 mg.
FLUCLOXACILINA SODIC|FLUCLOXACILLINUM NATRICUM (DCI)
N
SCH3
CH3
COOH
NHC
O
ON
O CH3Cl
F
Sarea de sodiu a acidului (2S, 5R, 6R)-6-3-(2-cloro-6-fluorofenil)-5-metil-4-izoxazolcarboxamido)- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-
carboxilic
• Sinonim: Floxacilin\.
• PF. FLOXAPEN (GlaxoSmithKline) - capsule 250 si 500 mg ; sirop (125 mg / 5 ml); pulbere pentru solutie injectabila (250 mg, 500 mg si 1000 mg).
Alte peniciline rezistente la penicilinază şi stabile la aciditatea gastrică
NAFCILINA SODIC|NAFCILLINUM NATRICUM (DCI)
N
SCH3
CH3
COO-
NHC
O
O
OC2H5
. H2ONa+
Sarea de sodiu a acidului (2S, 5R, 6R)-6-(2-etoxi-1-naftamido)- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
PF: UNIPEN (Wyeth Ayerst, SUA) – capsule 250 si 500 mg ; pulbere pentru solutie injectabila (1000 mg si 2000 mg).
Peniciline cu spectru de activitate lărgit
Aminopeniciline
AMPICILINA SODIC| AMPICILLINUM NATRICUM (DCI, FR X)
Na+
N
SCH3
CH3
COO-
NHC
O
CH
ONH2
(2S, 5R, 6R)-6-(R)-2-amino-2-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilat de sodiu
• Sinonim: Aminobenzilpenicilina.
Clorura acidului alfa-amino-fenil acetic
CH
NH2
+
6-APA trimetil- silil ester
C
N CH
CS
C
C
CH3
CH3
COOO
H2N
Si
CH3
CH3
CH3
H H
N
SCH3
CH3
COOH
NHC
O
CH
ONH2
Cl
OC
. HCl
dimetilanilinaapa
pH = 5
. 3 H2O
6-APA sare cu trietilamina
C
N CH
CS
C
C
CH3
CH3
COO-
O
H2NH H
N
SCH3
CH3
COOH
NHC
O
CH
ONH2
CH COOK
NH2
alfa-amino-fenilacetat de potasiu
+ CH3 C CH2
O
COOC2H5
acetil acetat de etil
-H2OCH COOK
N CCH3
CH2COOC2H5
Baza Schiff
CH COOK
NH
CH3C CH C
O
OC2H5
forma enaminica
(CH3)3C COClclorura acidului pivalic
- KClCH
NH
CH3C CH C
O
OC2H5
COO
C O
C(CH3)3
agent de acilare (anhidrida mixta)
NH(C2H5)3+
- (CH3)3C COOH
acid pivalicN
SCH3
CH3
COO-
NHC
O
CH
ON
C CH2COOC2H5H3C
NH(C2H5)3+
H2O (HCl)
- CO2
- C2H5OH
- CH3COCH3- (C2H5)3N . HCl Ampicilina
• PF. AMPICILINA (Antibiotice SA; Europharm SA; Lek Pharmatech; Ropharma, România) -
capsule cu 250 mg si 500 mg ampicilina anhidra, pulbere pentru suspensie orala (125 mg si 250
mg / 5 ml), flacoane cu 250 mg, 500 mg si 1000 mg pulbere uscata sterila ampicilina sodica pentru
administrare parenterala;
PAMECIL (Medochemie, Cipru) – pulbere pentru solutie injectabila (500 mg si 1000 mg)
STANDACILLIN (Biochemie, Austria) - capsule cu 250 mg si 500 mg ampicilina trihidrat;
granule pentru suspensie orala (125 mg si 250 mg / 5 ml), pulbere pentru solutie injectabila (500
mg, 1000 mg si 2000 mg).
Derivaţi biologic reversibili ai ampicilinei (proampiciline)
PIVAMPICILINA CLORHIDRATPIVAMPICILLINUM HYDROCHLORIDUM (DCI)
N
SCH3
CH3
COOCH2
NHC
O
CH
ONH2 OCO C(CH3)3
. HCl
(2S, 5R, 6R)-6-(R)-2-amino-2-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilat de pivaloil-oxi-metil
N
SCH3
CH3
COOCH2
NHC
O
CH
ONH2 OCO C(CH3)3
N
SCH3
CH3
COOH
NHC
O
CH
ONH2
+ CH2O + HOOC C(CH3)3
- H2O
PF: PONDOCILLIN (Leo Pharma, Danemarca; Norvegia; Suedia) – comprimate 500 mg; suspensie 35 mg /ml.
TALAMPICILINA CLORHIDRATTALAMPICILLINUM HYDROCHLORIDUM (DCI)
N
SCH3
CH3
COO
NHC
O
CH
ONH2
O
O
. HCl
(2S, 5R, 6R)-6-(R)-2-amino-2-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilat de 3-oxo-1,3-dihidroizobenzofuran-1-il
• Sinonim: Ampicilin-ftalidil clorhidrat
BACAMPICILINA CLORHIDRATBACAMPICILLINUM HYDROCHLORIDUM (DCI)
N
SCH3
CH3
COO
NHC
O
CH
ONH2 CH
CH3
O COOC2H5
. HCl
(2S, 5R, 6R)-6-(R)-2-amino-2-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilat de 1-(etoxi-carbonil-oxi)-etil
• PF: PENGLOBE (Astra Zeneca, UK-Suedia) – comprimate 200 mg.
HETACILINAHETACILLINUM (DCI)
N
SCH3
CH3
COOHO
N N
O
H3C CH3
H
Acid (2S, 5R, 6R)-6-(R)-2,2-dimetil-5-oxo-4-fenil-1-imidazolinil- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
• Sinonime: Etacilina; Fenazacilina.
N
SCH3
CH3
COOHO
N
SCH3
CH3
COOH
NHC
O
CH
ONH2
+ H3C C CH3
O
N N
O
H3C CH3
H
- H2O
METAMPICILINAMETAMPICILLINUM (DCI)
N
SCH3
CH3
COOH
NHC
O
CH
ON CH2
Acid (2S, 5R, 6R)-6-(R)-2-(metilen-amino)-2-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo
3. 2. 0 heptan-2-carboxilic
• PF: DOMPIL (Spyfarma, Spania) – capsule a 250 mg si 500 mg.
Derivaţi biologic ireversibili ai ampicilinei
AMOXICILINA TRIHIDRATAMOXICILLINUM TRIHYDRICUM (DCI, FR X)
N
SCH3
CH3
COOH
NHC
O
CH
ONH2
HO . 3 H2O
Acid (2S, 5R, 6R)-6-(R)-(-)-2-amino-2-(p-hidroxi-fenil)-acetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
• Sinonim: p-Hidroxiampicilin\.
CH
NH
CH3C CH C
O
OC2H5
COO
C OOC2H5
HOCH COONa
NH
CH3C CH C
O
OC2H5
HO
CH COONa+
NH2
HO
H2O
CO2-
N
SCH3
CH3
COOH
NHC
O
CH
ONH2
HO
CH3COCH3-
C2H5COOH-
N
SCH3
CH3
COOH
NHC
O
CH
ONH
HO
H3C C
CH C
OC2H5
O
C2H5 OH-
agent de acilare (anhidrida mixta)
NaCl-
C2H5O COCl
H2O-
acetil acetat de etil
CH3 C CH2
O
COOC2H5
fenil acetat de sodiualfa-amino-p-hidroxi
HH
C
C
CH
SC
N
CCH3
CH3
COOHO
H2N
6-APA
sare Dane
amoxicilina
• PF: AMOXICILINA (Antibiotice SA; Lek Pharmatech; Europharm; Arena Group, România /
Ozone Laboratories Ltd, UK) – capsule 250 mg si 500 mg; pulbere pentru suspensie orala (125
mg / 5 ml; 250 mg / 5 ml);
OSPAMOX (Sandoz GmbH, Austria) – comprimate filmate 500 mg si 1000 mg; capsule 250
mg; pulbere pentru suspensie orala (125 mg / 5 ml; 250 mg / 5 ml);
DISPAMOX (Lek Pharmatech, România) – comprimate dispersabile 1000 mg;
RANOXIL (Ranbaxy Laboratories Ltd, India) - pulbere pentru suspensie orala (125 mg / 5 ml;
250 mg / 5 ml).
AMOXIL (SmithKline Beecham, UK) - fiole a 250 mg, 500 mg sau 1 g amoxicilina sub forma
de sare de sodiu; capsule a 250 mg sau 500 mg; pulbere pentru preparare de sirop (125 sau 250
mg / 5 ml); pulbere pentru suspensie orala de uz pediatric (125 mg / 1,25 ml).
EPICILINAEPICILLINUM (DCI)
N
SCH3
CH3
COOH
NHC
O
CH
ONH2
Acid (2S, 5R, 6R)-6-(R)-2-amino-2-(1,4-ciclohexadien-1-il)-acetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
• Sinonim: Dihidroampicilina.
CH
NH2
COOHLi / NH3
NaOCH3
CH
NH2
COONa
acid alfa-aminofenil acetic
1,4-ciclohexadienil-alfa-amino-acetat de sodiu
CH3 C CH2
O
COOCH3
acetilacetat de metil
- H2O
CH
NH
COONa
CH3C CH C
O
OCH3
sare Dane
C2H5O COCl
- NaClCH
NH
COO
CH3C CH C
O
OCH3
C
O
OC2H5
anhidrida mixta
N
S
COOH
CH3
CH3
O
H2N
6-APA
C2H5OH
CO2
-
-
N
S
COOH
CH3
CH3
O
NHCH
NH
C
CH3C CH C
O
OCH3
O
CH3COOH
CH3COCH3
-
-
H2O
N
S
COOH
CH3
CH3
O
NHCH
NH2
C
O
epicilina
CICLACILINACYCLACILLINUM (DCI)
N
SCH3
CH3
COOH
NHC
O
ONH2
Acid (2S, 5R, 6R)-6-(1-aminociclohexancarboxamido)- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
• PF. CILINASE (Dovalle, Brazilia) – comprimate a 500 mg.
Amidinopeniciline
AMDINOCILINA
AMDINOCILLINUM (DCI)
N
SCH3
CH3
COOH
NCH
O
N
Acid (2S, 5R, 6R)-6-(hexahidro-1H-azepin-1-il)-metilenamino- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
• Sinonime: Mecilinam; Amidinopenicilina HX; Penicilina Hx.
• PF. COACTIN (Roche, Elvetia) – pulbere pentru solutie injectabila (250 mg, 500 mg şi 1000 mg).
AMDINOCILIN PIVOXIL
AMDINOCILLINUM PIVOXYLUM (DCI)
N
SCH3
CH3
COOCH2
NCH
OO C C(CH3)3
ON
(2S, 5R, 6R)-6-(hexahidro-1H-azepin-1-il)-metilenamino- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilat de 2,2-(dimetil-1-oxopropoxi) metil
• Sinonime: Pivmecilina; Pivamdinocilina.
N
SCH3
CH3
COOCH2
NCH
OO C C(CH3)3
ON
N
N
SCH3
CH3
COOH
NCH
O
+ CH2O + HOOC C(CH3)3- H2O
-Carboxipeniciline
CARBENICILINA
CARBENICILLINUM (DCI)N
S CH3
CH3
COOH
NHC
O
CH
OCOOH
Acid (2S, 5R, 6R)-6-(-carboxi-fenilacetamido)- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-
carboxilic
CH COOH
COOH
2 PCl5
- 2 HCl-2 POCl3
CH COCl
COCl
C C
COCl
O
cetena
N
SCH3
CH3
COOH
H2N
O
+
N
SCH3
CH3
COOH
NHC
O
CH
OCOCl
HOH
- HClN
SCH3
CH3
COOH
NHC
O
CH
OCOOH
• PF. CARBENICILINA (Antibiotice SA, România) - flacoane cu pulbere uscata sterila, sare de sodiu, echivalent cu 1 g sau 5 g carbenicilina.
INDANIL CARBENICILINA
INDANYL CARBENICILLINUM (DCI)
COO
O
CH
O
C NH
COOH
CH3
CH3S
N
Acid (2S, 5R, 6R)-6--(5-indaniloxi) carbonil-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
• Sinonim: Carindacilina.
• PF. GEOCILLIN (Pfizer, USA) – comprimate
FENIL CARBENICILINA
PHENYL CARBENICILLINUM (DCI)
CH3
CH3
NO
NH
O
CH
COO
C
COOH
S
Acid (2S, 5R, 6R)-6--(fenoxicarbonil)-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
• Sinonim: Carfecilina.
TICARCILINA
TICARCILLINUM (DCI)
N
S
COOH
CH3
CH3NHC
O
O
CH
COOH
S
Acid (2S, 5R, 6R)-6-(-carboxi-3-tienilacetamido)- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
N
S
COOH
CH3
CH3NHC
O
O
CH
COOH
S
S
CH
COOH
COClSOCl2
S
CH
COOH
COOH
N
S
COOH
CH3
CH3H2N
O+
- HCl
• PF. TICAR (SmithKline Beecham, USA) – pulbere sterila injectabila (1 g si 5 g ticarcilina);
TICARPEN (SmithKline Beecham, Fran]a; Olanda; Spania)
TEMOCILINA
TEMOCILLINUM (DCI)
N
SCH3
CH3
COOH
NHC
O
CH
OCOOH
OCH3S
Acid (2S, 5R, 6R)-6-(carboxi-3-tienilacetil) amino-6-metoxi- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
• PF: NEGABAN (Eumedica, Elvetia) - pulbere sterila injectabila (1 g temocilina sodica).
Ureidopeniciline
PIPERACILINA
PIPERACILLINUM (DCI)
N
OC
NHO
CH
O
C NH
COOH
CH3
CH3S
N
N
C2H5
O
O
Acid (2S, 5R, 6R)-6-(R)-2-(4-etil-2,3-dioxo-1-piperazin-carboxamido)-2-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-
azabiciclo 3. 2. 0 heptan-2-carboxilic
N
S
COOH
CH3
CH3NHC
O
O
CH
NH
NH2
CH COOH + NN
O O
H5C2 COCl(C2H5)3N
(C2H5)3NH Cl-+
-
N
N O
O
C
C2H5
O
NH
CH COOH
N
S
COO-
CH3
CH3H2N
O(C2H5)3NH
++
ClCOOC2H5
C O
N
N O
O
C2H5
acid -(4-etil-2,3-dioxo-1-piperazino-
carbonilamino)-fenilacetic
-fenilglicina clorura de 4-etil-2,3-dioxo-1-piperazino-carbonil
• PF: PIPRIL (Wyeth, Austria; Irlanda) - pulbere sterila injectabila (1 g sau 2 g piperacilina sodica);
PIPRACIL (Lederle, USA)
AZLOCILINA
AZLOCILLINUM (DCI)
N
SCH3
CH3
COOH
NHC
O
CH
ONH
C O
N
N
O
H
Acid (2S, 5R, 6R)-6-(R)-2-(2-oxo-1-imidazolidin-
carboxamido)-2-fenilacetamido- 3,3-dimetil-7-oxo-
4-tia-1-azabiciclo 3. 2. 0 heptan-2-carboxilic
N
S
COOH
CH3
CH3NHC
O
O
CH
NH2
N N
O
C
O
Cl H+
(C2H5)3N
(C2H5)3NH Cl-+
-
N
S
COOH
CH3
CH3NHC
O
O
CH
NH
N
N
O
C O
H
ampicilinaN-cloro-carbonil-imidazolidin-
2-ona
• PF: SECUROPEN (Bayer, Germania; Austria; Irlanda) – pulbere sterila pentru solutie injectabila (2g si 5 g azlocilina).
MEZLOCILINA
MEZLOCILLINUM (DCI)
N
SCH3
CH3
COOH
NHC
O
CH
ONH
C O
N
N
O
SO2 CH3
Acid (2S, 5R, 6R)-6-(R)-2-3-(metil-sulfonil)-2-oxo-1-imidazolidin-carboxamido-
2-fenilacetamido- 3,3-dimetil-7-oxo-4-tia-1-azabiciclo 3. 2. 0 heptan-2-
carboxilic
• PF. BAYPEN (Bayer, Germania; Austria; Fran]a; Italia; Spania; Israel) - pulbere sterila pentru
solutie injectabila (echivalentul a 1g si 2 g mezlocilina).
top related