Derivaii pirazolului

pirazol pirazolin pirazolidin

enol iminoimid iminodoacid iminoimidolClasificarea 1. Derivaii pirazolinei fenazon (antipirin), metamizol de sodiu (analgina):

pirazolon-52. Derivaii pirazolidindionei fenilbutazon (butadion):

pirazolidindion-3,5

Phenazonum Fenazon Antipyrinum 1-fenil-2,3-dimetilpirazolon-5

Obinerea:

fenilhidrazina ester etilic al acidului etilacetatul de etil acetic

ester metilic

benzensulfacidului fenilhidrazona 1-fenil-3-metilpirazolon-5 etilacetatului de etil

Benzensulfonat fenazonei

fenilhidrazina dicheten 1-fenil-3-metilpirazolon-5

sau

Identificarea: nregistrarea spectrelor UV- i IR;

nitrozofenazon feropirina Cu reactivul Mayer, soluia tanin, acid picric etc. La interaciunea nitrozofenazonei cu 1-naftilamin se obine colorantul azoic (coloraie roie):

Nitrozofenazon poate reaciona cu 1-naftol:

Dozarea: Metoda iodometric:

Metoda iodclorimetric:

Metamizolum natricum

Metamizol sodi

Analginum1-fenil-2,3-dimetil-4-metilaminopirazolon-5-N-metansulfonat de sodiuObinerea:

benzaldehida1-fenil-2,3-dimetil- 1- fenil -2,3- dimetil -4-benziliden-

-4-aminopirazolon-5 - aminopirazolon -5

dimetilsulfat sarea quaternar

1-fenil-2,3-dimetil- -4-metilamonipirazolon-5

Identificarea:

Spectrele IR- (FS XII);

Spectrele UV soluia metamizolului de sodiu n acid clorhidric 0,1 mol/l prezint un maxim la 258 nm (FS XII);

50 mg substan se dizolv n 1 ml peroxid de hidrogen 30%, apare coloraie albastru-deschis, ce dispare n timp, treptat, soluia se coloreaz n rou (FS XII); Na+ cu piroantimonat de potasiu ([Sb(OH)6]), se obine pricipitat dens alb;

Na+ + [Sb(OH)6] Na[Sb(OH)6] Cu iodat de potasiu (IO3) n mediu acidului clorhidric coloraie zmeurie precipitat brun:

monometilamonofenazon

formarea compusului aurinic:

cu soluia de cloramin sau clorur de fier (III) coloraie albastr ce dispare treptat; cu soluia nitrat de argint precipitat alb negru.Dozarea:

Metoda iodometric:Phenilbutazonum

Fenilbutazon

Butadionum

1,2-difenil-4-butilpirazolidin-dion-3,5

Obinera:

nitrobenzen hidrazobenzen

Cloranhidrida acidului n-butil-

-malonicIdentificarea: nregistrarea spectrelor UV- i IR;

nclzirea cu acid clorhidric: Reacia de formare a srurilor:

Reacia de oxidare:

hidrazobenzen azobenzenDozarea: Metoda alcalimetric:

Metoda iodclorimetric:

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