informaŢii iacob maria speranta personale

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Curriculum Vitae Iacob Maria Speranta © Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 1 / 18 INFORMAŢII PERSONALE IACOB MARIA SPERANTA Adresa (spital): Centrul pentru Boli Digestive si Transplant Hepatic Institutul Clinic Fundeni Şoseaua Fundeni nr. 258 022328 Bucureşti, România +4021 2750500(centrala); Fax: +40213180447(secretariat); [email protected] Sexul F | Data naşterii 08/04/1977 | Naţionalitatea romana EXPERIENŢA PROFESIONALĂ EDUCAŢIE ŞI FORMARE 2002 Diploma de medic: 545/ 21.03.2002 Seria T Nr. 0028346 Romania 2002 Medic rezident gastroenterologie, Certificat 073/ 12.12.2002 2007 Medic specialist gastroenterologie: OMS 2140/2007 2013 Medic primar gastroenterologie: OMS 1044/2013 Etape medicale si universitare In prezent Pozitia ocupata: Sef de lucrari, Medic primar gastroenterologie Tipul sau sectorul de activitate: Asistenta medicala de specialitate, gastroenterologie 2016 - prezent Sef de lucrari UMF Carol Davila 2013 -prezent Medic primar gastroenterologie - OMS 1044/2013 2007 - prezent Medic specialist gastroenterologie - OMS 2140/2007. Centrul pentru Boli Digestive si Transplant Hepatic, Institutul Clinic Fundeni, Bucuresti. 2007 - 2010 Cercetator prin concurs validat de Academia de Stiinte Medicale cu adeverinta nr 496/2007. Centrul pentru Boli Digestive si Transplant Hepatic, Institutul Clinic Fundeni, Bucuresti 2002-2006 Medic rezident gastroenterologie - Certificat 073/ 12.12.2002. Centrul pentru Boli Digestive si Transplant Hepatic, Institutul Clinic Fundeni, Bucuresti. 2003-2007 Asistent de cercetare, prin concurs validat de Academia de Stiinte Medicale cu adeverinta nr 91/2003. Centrul pentru Boli Digestive si Transplant Hepatic, Institutul Clinic Fundeni, Bucuresti

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Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 1 / 18

INFORMAŢII

PERSONALE

IACOB MARIA SPERANTA

Adresa (spital): Centrul pentru Boli Digestive si Transplant Hepatic

Institutul Clinic Fundeni

Şoseaua Fundeni nr. 258

022328 Bucureşti, România

+4021 2750500(centrala);

Fax: +40213180447(secretariat);

[email protected]

Sexul F | Data naşterii 08/04/1977 | Naţionalitatea romana

EXPERIENŢA

PROFESIONALĂ

EDUCAŢIE ŞI

FORMARE

2002 Diploma de medic: 545/ 21.03.2002 Seria T Nr. 0028346 Romania

2002 Medic rezident gastroenterologie, Certificat 073/ 12.12.2002

2007 Medic specialist gastroenterologie: OMS 2140/2007

2013 Medic primar gastroenterologie: OMS 1044/2013

Etape medicale si

universitare

In prezent

Pozitia ocupata: Sef de lucrari, Medic primar gastroenterologie

Tipul sau sectorul de activitate: Asistenta medicala de specialitate,

gastroenterologie

2016 - prezent Sef de lucrari UMF Carol Davila

2013 -prezent Medic primar gastroenterologie - OMS 1044/2013

2007 - prezent Medic specialist gastroenterologie - OMS 2140/2007. Centrul pentru Boli

Digestive si Transplant Hepatic, Institutul Clinic Fundeni, Bucuresti.

2007 - 2010 Cercetator prin concurs validat de Academia de Stiinte Medicale cu adeverinta nr

496/2007. Centrul pentru Boli Digestive si Transplant Hepatic, Institutul Clinic

Fundeni, Bucuresti

2002-2006 Medic rezident gastroenterologie - Certificat 073/ 12.12.2002. Centrul pentru

Boli Digestive si Transplant Hepatic, Institutul Clinic Fundeni, Bucuresti.

2003-2007 Asistent de cercetare, prin concurs validat de Academia de Stiinte Medicale cu

adeverinta nr 91/2003. Centrul pentru Boli Digestive si Transplant Hepatic,

Institutul Clinic Fundeni, Bucuresti

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 2 / 18

1995-2001 Universitatea de Medicina si Farmacie „Carol Davila” Bucuresti

2002

Diploma de licenta Nr 545/21.03.2002, Titlul de Doctor - Medic, absolvent UMF

„Carol Davila Bucuresti”, Facultatea de Medicina.

2001-2002 Spitalul Universitar de Urgenta, Bucuresti : 1 stagiu clinic de Neonatologie si

Institutul Clinic Fundeni, Clinica de Pediatrie - 1 stagiu clinic de Pediatrie in

Cadrul Rezidentiatului de Pediatrie

2002-2007 Centrul de Gastroenterologie si Hepatologie Fundeni: medic rezident

gastroenterologie

2006-2010 Studii doctorale sub coordonarea Prof Dr. Irinel Popescu

2007-2010 Bursa de cercetare pentru Tinerii Doctoranzi acordata de Consiliul National de

Cercetare Stiintifica

2010 Doctor in Medicina. Ordin MECTS Nr 4387/06.06.2011. Titlul Tezei de Doctorat:

„Hepatita recurenta C posttransplant hepatic – strategii terapeutice si factori

asociati cu recurenta severa”

2011 Obtinerea Diplomei Europene in Medicina de Transplant – Modulele 1 (Trunchi

Comun) si 4 (Transplantul hepatic) prin examen sustinut la Glasgow pe 7

Septembrie 2011

Afiliere la societati si

publicatii profesionale

2001 - in prezent Membru al Societatii Romane de Gastroenterologie & Hepatologie (SRGH)

2001 – in prezent Membru al Societatii Romane de Endoscopie Digestiva

(SRED)

2002 – 2004 Membru al Socientatii Romane de Nutritie Enterala si Parenterala (ROSPEN)

2002 – 2004, 2018- in

prezent

Membru a ROMTRANSPLANT

2003 - 2008 Membru al Asociatiei Internationale a Chirurgilor si Gastroenterologilor (IASG)

2004 - 2008 Membru al American College of Gastroenterology (ACG)

2005 – in prezent Membru al European Association for the Study of the Liver (EASL)

2007- in prezent Membru al Clubului Roman de Boala Crohn si Colita Ulcerativa (RCCC)

2008 – in prezent Membru al Societatii Internationale de Transplant (TTS)

2008 – in prezent Membru al Societatii Europene de Transplant de Organe (ESOT)

2009 – in prezent Membru Fondator al “Women Leaders in Transplantation” (WLIT)

2010 - 2011 Membru al Societatii Europene de Crohn si Colita (European Crohn’s and

Colitis Organization) (ECCO)

2018 - in prezent Membru in Comitetul Editorial al „Surgery, Gastroenterology and Oncology”

- Official journal of the International Association of Surgeons,

Gastroenterologists and Oncologists

COMPETENΤE

PERSONALE Diploma Europeana in Medicina de Transplant – Modulele 1 (Trunchi

Comun) si 4 (Transplantul hepatic) - supraspecializarea Transplant Hepatic

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 3 / 18

Limba(i) maternă(e)

Romana

Alte limbi străine cunoscute ΙNΤELEGERE VORBIRE SCRIERE

Ascultare Citire Participare la

conversaţie Discurs oral

Engleza C2 C2 C2 C2 C2

Franceza B2 B2 B2 B2 B2

Germana A2 A2 A2 A2 A2

Scrieţi denumirea certificatului. Scrieţi nivelul, dacă îl cunoaşteţi. Niveluri: A1/2: Utilizator elementar - B1/2: Utilizator independent - C1/2: Utilizator experimentat

Cadrul european comun de referinţă pentru limbi străine

Competenţe de comunicare Bune competenţe de comunicare dobândite prin experienţa in cadrul activitatii

clinice si de cercetare de peste 14 ani, participant cu lucrari de specialitate la

numeroase manifestari stiintifice internationale si nationale

Autor de lucrari publicate in reviste cu peer review si recenzori internationali

Functii administrative

si de conducere

2012 – 2019

2018 – prezent

2019 – 2023

Reprezentant National in Bordul European de Medicina de Transplant

Secretar al RoALD (Romanian Association for Liver Diseases)

Secretar Senior al Bordului European de Medicina de Transplant

2014 - prezent Responsabil cu gestionarea datelor din Registrul National de Transplant in cadrul

Institutului Clinic Fundeni Bucuresti – Centrul pentru Boli Digestive si Transplant

Hepatic conform Ordinului ministrului Sanatatii 983/26 August 2014

Competente dobandite la

locul de munca

Endoscopie digestiva diagnostica (abilitate inclusa in standardul profesional).

Ultrasonografie generala (abilitate inclusa in standardul profesional).

Competente informatice Utilizator experimentat PC (MS Office, Windows).

Pregătire

postuniversitară

(CURSURI ŞI

SPECIALIZĂRI)

1 Noiembrie 2000 Curs Precongres: Simpozionul National de Gastroenterologie, Hepatologie si

Endoscopie Digestiva, Bucuresti, 2000

Aprilie 2001 EASL Post-Graduate Course: Clinical Management of Portal Hypertension and Its

Complications, 36-th EASL Meeting, Prague, CZECH REPUBLIC

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 4 / 18

Martie 2002 POSTGRADUATE COURSE IN HEPATO-GASTROENTEROLOGY organized

by The National French Society of Gastroenterology, Nantes, FRANCE

Aprilie 2002 Stagiu practic 2 saptamani in Clinica de Gastroenterologie a Spitalului “EDOUARD

HERRIOT”, LYON, FRANCE

6-7 Decembrie 2002 Simpozionul “Afectiuni peptice digestive la inceputul mileniului III – optiuni

diagnostic, solutii terapeutice”, Campina, Romania

18 Februarie 2003 Simpozionul “Noua generatie de terapie antivirala in hepatita cronica C”, Hotel

Crowne Plaza, Bucuresti

17-18 Martie 2003 Tehnica de montare endoscopica a gastrostomei percutane, Institutul Clinic Fundeni,

Bucuresti

9-11 Aprilie 2003 Al cincilea simpozion si curs postuniversitar al IASG “Actualitati in bolile ficatului”,

Bucuresti, Romania

24 Septembrie 2003 PRECONGRESS COURSE “Actualities in gastroenterology and hepatology”, 9-th

Congress of Gastroenterology, Hepatology and Gastrointestinal Endoscopy, Craiova,

Romania

3 Octombrie 2003 SIMPOZIONUL “ROLUL LIMFOCITELOR T IN IMUNOPATOGENEZA

HEPATITELOR CRONICE”, INSTITUTUL CLINIC FUNDENI, BUCURESTI

Octombrie 2003 ADVANCED POSTGRADUATE COURSE IN GASTROENTEROLOGY

organized by The Holland Digestive Disease Week Foundation, The Netherlands

19-23 Octombrie

2003

10 th CLINICAL COURSE OF EUROPEAN SOCIETY FOR CLINICAL

NUTRITION AND METABOLISM, Izvorani, Romania

Decembrie 2003 EASL School of Hepatology Course 1 – Chronic Liver Diseases

Geneva, Switzerland

12 Martie 2004 European Postgraduate Gastro-surgical School, 4th

Amsterdam International Update

on Hepatology: Hepatitis B and C and Hepatocellular Carcinoma, Academic Medical

Center, Amsterdam, The Netherlands

3-4 aprilie 2004 POSTGRADUATE COURSE IN HEPATO-GASTROENTEROLOGY organized

by The National French Society of Gastroenterology, Paris, FRANCE

Iunie 2004 EASL School of Hepatology Course 2 – Complications of cirrhosis and liver cancer,

Barcelona, SPAIN

Septembrie 2004 PRECONGRESS COURSE: “ACTUALITATI IN GASTROENTEROLOGIE,

HEPATOLOGIE SI ENDOSCOPIE DIGESTIVA”. The XXVth National Symposium

of Gastroenterology, Hepatology and Gastrointestinal Endoscopy, Constanta,

Romania

13 Octombrie 2004 SIMPOZIONUL “STEATOZA HEPATICA NONALCOOLICA”, SIBIU,

ROMANIA

25 Septembrie 2004 EASL Post-Graduate Course: Liver Transplantation – State of the Art and Novel

Developments, 12th UEGW, Prague, CZECH REPUBLIC

11-12 Noiembrie 2004 Curs de Nutritie Clinica si Metabolism, Poiana Brasov, Romania

13-14 Aprilie 2005 EASL Post-Graduate Course: The Liver Clinic in the Post-Genomic Era, 40 th EASL

Meeting, Paris, France

1 Iunie – 30

Noiembrie 2005

DAAD Scholarship – LIVER TRANSPLANTATION SPECIALISATION,

University Hospital Essen, Germany

12-16 Decembrie

2005

Simpozionul “Clasic si modern in patologia digestiva”, Institutul Clinic Fundeni,

Bucuresti

12-14 Ianuarie 2006 Monothematic Conference: Liver Transplantation for Viral Hepatitis, Paris, Franta

3 Martie 2006 Workshop cu participare internationala cu tema: “Impactul clinic al ecoendoscopiei

diagnostice si terapeutice”, Institutul Clinic Fundeni, Bucuresti

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 5 / 18

26-30 Aprilie 2006 EASL Postgraduate Course: “Immunological phenomena in hepatitis C in and

outside of the liver”, the 41st Annual Meeting of the European Association for the

Study of the Liver, Vienna, Austria

20-21 Mai 2006 AGA Postgraduate Course: “Recognizing and reducing risk in GI practice”, Digestive

Disease Week, Los Angeles, United States

21 Mai 2006 SSAT (The Society for Surgery of the Alimentary Tract) Postgraduate Course, Los

Angeles, CA, USA.

14 Iunie 2006 Cursul Pre-Simpozion “Curs de Gastroenterologie, Hepatologie si Endoscopie

Digestiva”, Al XXVII-lea Simpozion National de Gastroenterologie, Hepatologie si

Endoscopie Digetiva”, Poiana Brasov – Hotel Piatra Mare

2006 Simpozionul “Sindromul Barrett – de la boala de reflux gastroesofagian la

adenocarcinomul esofagian”, Institutul Clinic Fundeni, Bucuresti

Octombrie 2006 VERUM.EDU seminar on “Basics on Good Clinical Practice for investigators”

Octombrie 2006 ESGE Postgraduate Course: “Endoscopic Oncology; Practice of Endoscopy”, 14th

United European Digestive Week, Berlin, Germany

Octombrie 2006 EASL Postgraduate Course: “Current and Future Therapeutic Options for Viral

Hepatitis”, 14th United European Digestive Week, Berlin, Germany

1 Februarie – 31

Decembrie 2006

Curs deschis la distanta, Universitatea de Medicina si Farmacie “Iuliu Hatieganu”

Cluj-Napoca

11 Aprilie 2007 EASL Postgraduate Course: “The microscope at the bedside”, the 42nd

Annual

Meeting of the European Association for the Study of the Liver, Barcelona, Spain

11-12 Iunie 2007 Third International Symposium on Living Donor Organ Transplantation, Essen,

Germany

27-28 Octombrie

2007

Postgraduate Course: “Recent Advances in Imaging for

Gastrointestinal and Liver Diseases”, 15th United European Digestive Week, Paris,

France

Octombrie 2007 EASL Postgraduate Course:”Portal hypertension”, 15th United European Digestive

Week, Paris, France

23-24 Aprilie 2008 EASL Postgraduate Course: “Complications of portal hypertension”, the 43rd Annual

Meeting of the European Association for the Study of the Liver, Milan, Italy

17-18 Mai 2008 Spring Postgraduate Course: Gastroenterology and Hepatology 2008: Challenges and

Controversies, San Diego CA, USA.

31 Mai- 3 Iunie 2008 The Postgraduate course: “Ultrasound in Gastroenterology and Hepatology”,

EUROSON 2008, Timisoara, Romania

5 Decembrie 2008 Simpozionul “Provocarile terapiei optime in hepatita cronica B”, Institutul National

de Boli INfectioase “Prof Dr Matei Bals”, Bucuresti

17 Iunie 2009 9th ECCO Educational Workshop, Cluj-Napoca, Romania

18 Iunie 2009 Curs precongres. Al XXIX-lea Simpozion National de Gastroenterologie, Endoscopie

Digestiva si Hepatologie, Cluj Napoca

Ianuarie 2009-

Decembrie 2009

Doctoral research fellowship in liver transplantation, University Hospital Essen,

Germany

21-22 Noiembrie

2009

17th UEGW Postgraduate Teaching Programme, Londra, Marea Britanie

14-15 Aprilie 2010 Postgraduate Course:MANAGEMENT OF ACUTE CRITICAL CONDITIONS IN

HEPATOLOGY, 45 Annual Meeting of EASL, Viena, Austria

4 Iunie 2010 Simpozionul National „IBISCUS Bucharest Contrast Enhanced Ultrasound –

Routine Tool in General Imaging”, Bucuresti

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 6 / 18

9-10 Iunie 2010 Curs Precongres: Al XXX-lea Simpozion National de Gastroenterologie, Endoscopie

Digestiva si Hepatologie, Craiova

24-25 Septembrie

2010

Al II-lea Simpozion National de Boli Inflamatorii Cronice Intestinale cu participare

internationala, Mamaia, Romania

27-30 Septembrie

2010

IASGO CME Postgraduate Course “Liver Transplantation – An interdisciplinary

Approach”, Essen, Germany

22-23 Octombrie

2011

Postgraduate Teaching Programme, 19th UEGW Stockholm, Sweden

4 Noiembrie 2011 AASLD/ILTS Transplant Course: Liver Transplant Immunosuppression: “Does One

Size Fit All?”; 62nd

AASLD Meeting, San Francisco, USA

18-19 Aprilie 2012 EASL Postgraduate Course: Parasitic, “Imported” and Alcoholic Liver Disease,

Barcelona, Spain

14 Iunie 2012 EAGEN Postgraduate Course: “Complication of Inflammation and Infection in the

Gastrointestinal Tract”, Targu Mures, Romania

14-15 Iulie 2012 Postgraduate Weekend, 24th International Congress of the Transplantation Society,

Berlin, Germania

20 Septembrie 2012 27th ECCO Educational Workshop: „ECCO Guidelines”, Sibiu 20 Septembrie 2012

9-10 Aprilie 2013 Clinical Observation Program – Liver Unit, Vall d’Hebron University Hospital

Barcelona, Spain

9-10 Aprilie 2014 EASL-IASL Postgraduate course: “Acute Liver failure/Acute on Chronic liver

failure: perspective of the East and West”, London, United Kingdom

25-26 Aprilie 2014 Up-To-Date in Hepatology, Annual Course – “Viral Hepatitis and Liver Cirrhosis” –

Current Challenges and Future Directions, Bucharest, Romania

26-28 Iunie 2014 “Scoala de vara Medicina Interna-Gastroenterologie”, Paltinis, Romania

6 Martie 2015 ESOT Course: Liver transplantation in HCV positive recipients: facing a new Era

22-23 Aprilie 2015 EASL Postgraduate course – “Metabolic liver disease”, Viena Austria

22 Aprilie 2015 EASL-ILTS-ELITA-LICAGE Post Graduate Course – “Liver Transplant”, Viena,

Austria

27-28 Mai 2015 Up-To-Date in Hepatology, Annual Course – “Portal hypertension and its

complications after Baveno VI Consensus Conference”; “Viral Hepatitis Anno 2015:

Curring the Disease”, Bucharest, Romania

29-30 Mai 2015 EASL Monothematic Conference: “Liver Diseases in resource-limited Settings”

Bucharest, Romania

9 Iunie 2015 Cursul de Gastroenterologie si Hepatologie, Iasi 10-13 iunie 2015

26-28 Iunie 2015 15th International Symposium on Viral Hepatitis and Liver Disease (ISVHLD),

Berlin, Germany

8 Iulie 2015 Current controversies in liver transplantation – Satellite symposium to the ILTS 21st

Annual International Congress, Chicago USA

10 Iulie 2015 Managing HCV in Liver Transplant: Optimizing Success with New DAA Regimens,

Chicago, USA

17-19 Martie 2016 Al 11 lea Simpozion Nicolae Cajal – Mecanisme Moleculare ale Bolilor Acute

si Cronice, Bucuresti, Romania

28-29 Aprilie 2016 3rd UpDate on Hepatology, Course Bucharest 2016, Romania, 28-29 Aprilie

2016, Bucuresti, Romania – „Clinical Challenges, Unmet Needs and Emerging

Therapies in Hepatology”

28-29 Octombrie

2016

Hepatology Academy Preceptorship Program, Universitats Klinikum Frankfurt

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 7 / 18

11 Noiembrie 2016 AASLD/ILTS Transplant Course “The Next 10 Years: Innovations

Transforming Outcomes in Liver Transplantation” Boston, Massachussets

12-13 Decembrie

2016

Hepatology Academy Preceptorship Center of Excellence Curriculum,

University of Milan, Milan, Italy

29 January 2017 International Hepatitis C Exchange, Paris, France

30-31 January 2017 10th Paris Hepatology Conference – International Conference on the

Management of Liver Diseases

2-5 February 2017 EASL HCC Summit 2017, Geneva, Elvetia

3 Martie 2017 Conferinta „Tratamente inovative in Oncologie – Editia a IIIa – Analiza

moleculara si terapia individualizata in cancer”, Bucuresti, Romania

6-7 Aprilie 2017 4th UpDate on Hepatology, Course Bucharest 2016, Hepatology 2017 – A

panoramic view, Romania, 6-7 Aprilie 2017, Bucuresti, Romania

19 April 2017 PGC on Liver Transplantation: Current challenges in liver transplantation, The

International Liver Congress (ILC) 2017, Amsterdam, Olanda

19 April 2017 PGC on Liver Transplantation: Liver transplantation for viral hepatitis, ILC

2017, Amsterdam, Olanda

19 April 2017 BSS – Hepatic regenerative medicine: Artificial and natural 3D scaffolds for

liver tissue bioengineering, ILC 2017, Amsterdam, Olanda

20 April 2017 PGC – A multidisciplinary approach to patients with liver disease:

Hepatocellular carcinoma, ILC 2017, Amsterdam, Olanda

20 April 2017 PGC – A multidisciplinary approach to patients with liver disease: Non-

alcoholic fatty liver disease, ILC 2017, Amsterdam, Olanda

12-13 May 2017 Hepatology Academy, Standalone Meeting, Paris, Franta

22-24 Iunie 2017 Al 37lea Congres National de Gastroenterologie, Hepatologie si Endoscopie

Digestiva, Bucuresti, Romania

8-9 Septembrie 2017 Pancreatic Fest 2017, Bucharest, Romania

15-16 September

2017

Hope for Cure Vernissage, Budapesta, Hungary

24-27 Septembrie

2017

18th Congress of the European Society for Organ Transplantation, Barcelona,

Spania

28-30 September

2017

9th National Symposium on Inflammatory Bowel Disease, Bucharest, Romania

6-8 October 2017 Congresul National de Radiologie si Imagistica Medicala, Bucuresti, Romania

16-17 October 2017 King’s College Hospital London – Hepatology Academy Perceptorship

10-11 November 2017 Liver Elastography Course, Timisoara, Romania

29 March 2018 Al X-lea Congres al Asociatiei Romtransplant, Bucuresti, Romania

11-15 April 2018 The International Liver Congress, Paris, France

26-27 April 2018 5th UpDate on Hepatology Course – Best Practices in Clinical Hepatology,

Bucharest, Romania

24-26 May 2018 Al 38-lea Congres National de Gastroenterologie, Hepatologie si Endoscopie

Digestiva, Craiova, Romania

2-5 June 2018 Digestive Disease Week 2018: Monumental Developments in Science and

Medicine, Washington, USA

17 Septembrie 2018 Simpozion Stiintific Aniversar – 60 ani de SRGH

19-21 Septembrie

2018

National Congress of the Romanian Association

of Hepato-Bilio-Pancreatic Surgery and Liver Transplantation – 12th

edition,

Cluj Napoca, Romania

3-6 Octombrie 2018 Zilele Institutului Clinic Fundeni 2018

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 8 / 18

1-4 aprilie 2019 TTT (Train the Trainers) Workshop organized by World Gastroenterology

Organisation (WGO), Bucuresti, Romania

5-6 Aprilie 2019 6th

UpDate on Hepatology Course “From theory to Practice in Liver Diseases,

Bucuresti, Romania

11-14 Aprilie 2019 The International Liver Congress (ILC) 2019, Vienna, Austria

10-11 Aprilie 2019 Postgraduate Course “End stage Liver Disease”, ILC 2019, Vienna, Austria

19-20 Aprilie 2019 Corelatii anatomopatologice si clinice in gastroenterology, Curs-editia I,

Athenee Palace Hilton - Bucuresti

6-8 Iunie 2019 Al 39 lea Congresul National de Gastroenterologie, Hepatologie si Oncologie

Digestiva, Timisoara, Romania

8-10 Iulie 2019 Zilele Institutului Clinic Fundeni 2019

15-18 Septembrie

2019

19th Congress of the European Society for Organ Transplantation, Copenhaga,

Danemarca

19-21 Septembrie

2019

Digestive Endoscopy Cluj 2019

7th

Transylvanian Meeting for Liver Interventions

8-12 Noiembrie 2019 The Liver Meeting, AASLD, Boston, USA

22 Noiembrie 2019 CURS “Amiloidoza… de la A la Z”, Bucuresti

28-29 Februarie 2020 Cursul de Statistica Medicala sustinut la Centrul de Excelenta in Medicina

Translationala, Bucuresti

4 Mai 2020 Management of Transplant Programs during the COVID19 Pandemic- Part II

15 Iunie 2020 The COVID-19 pandemic: Lessons learnt from Italy

25 iunie 2020 COVID-19 & the Liver: Chronic Liver Disease and Transplant

28 iulie 2020 Romania 2030 fara Hepatite - Hepatitele virale in timpul si dupa pandemia

COVID-19

27-29 august 2020 The digital International Liver Congress 2020

13-16 Septembrie

2020

28th International Congress of the Transplantation Society - TTS2020 Virtual

23-26 septembrie

2020

National Congress of the Romtransplant Association – The 11th edition - online

14 august – 14

octombrie 2020

2020 Transplant Hepatology Board Review Course

6-8 noiembrie 2020 7 th UpDate on Hepatology Course Virtual Experience Bucharest 6th-8th November

2020

15-17 noiembrie 2020 ESOT TLJ 2.0 – online experience

Premii, burse,

recunoasterea

meritului

stiintific

Premii Internationale (22)

18-22 Aprilie 2001 Travel Bursary Award, 36th Annual Meeting of European Association for the Study of the

Liver (EASL), Prague, Czech Republic

28 Septembrie – 3

Octombrie 2001

Travel Bursary Award, Falk Symposia No. 124-126, “Progress in Gastroenterology and

Hepatology” Hannover, Germany

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 9 / 18

1-4 Noiembrie

2001

Certificate of appreciation in recognition of scientific excellence in the free paper (poster)

category: Liver and Biliary Diseases

11th World Congress of the International Association of Surgeons and Gatroenterologists

(IASG), Heraklion, Crete-Greece

23-27 Martie 2002 Bursary Award, The French Days of Digestive Pathology, Nantes, France

18-21 Aprilie 2002 Travel Bursary Award – Best Eastern European Abstract, 37th Annual Meeting of European

Association for the Study of the Liver (EASL), Madrid, Spain

12-17 Octombrie

2004

Travel Bursary Award, Falk Symposia No. 142-144, “Gastroenterology Week Freiburg

2004” Freiburg, Germany

13-17 Aprilie 2005 Young Investigator Full Bursary Award, 40th Annual Meeting of European Association for

the Study of the Liver (EASL), Paris, France

26-30 Aprilie 2006 Young Investigator Full Bursary Award, 41st Annual Meeting of European Association for

the Study of the Liver (EASL), Vienna, Austria

23-24 Martie 2007 Travel Bursary Award, Falk Symposium No. 158, “Intestinal Inflammation and Colorectal

Cancer” Seville, Spain

23-27 Aprilie 2008 Young Investigator Full Bursary Award, 43rd Annual Meeting of European Association for

the Study of the Liver (EASL), Milan, Italy

28 Iunie -1 Iulie

2008

Invited at TTS New KOL Meeting as New Key Opinion Leader (nKOL), Sankt Petersburg,

Russia – “Real time elastography – a noninvasive tool for evaluation of recurrent hepatitis C

following liver transplantation.”

10-14 August 2008 Travel Scholarship,The XXII International Congress of The Transplantation Society, Sydney,

Australia

17 Septembrie

2008

First prize: Falk Workshop “Strategies of Cancer Prevention in Gastroenterology”, Mainz,

Germany for the paper “Early Diagnosis of small hepatocellular carcinoma in cirrhotic

patients using real-time elastography”

17 Septembrie

2008

Travel Bursary Award, Falk Workshop “Strategies of Cancer Prevention in

Gastroenterology”, Mainz, Germany

18-19 Septembrie

2008

Travel Bursary Award, Falk Symposium no 166, “GI Endoscopy – Standards and

Innovations”, Mainz, Germany

20-21 Septembrie

2008

Travel Bursary Award, Falk Symposium no 167, “Liver under constant attack – from fat to

viruses”, Mainz, Germany

17-18 Octombrie

2009

Travel Bursary Award, Falk Symposium no 171, “Liver and metabolic syndrome”,

Hannover, Germany

14-18 April 2010 Young Investigator Full Bursary Award, 45th Annual Meeting of European Association for

the Study of the Liver (EASL), Vienna, Austria

15-19 August 2010 Emerging Economy Travel Award, The XXIII International Congress of The

Transplantation Society, Vancouver, Canada : P37.57 – Survival outcomes following liver

transplantation (SOFT) score - A useful predictor of short term mortality in Romanian

Liver Transplant Program

30 March-3 April

2011

Young Investigator Full Bursary Award, The International Liver Congress 2011 - 46th

Annual Meeting of European Association for the Study of the Liver (EASL), Berlin,

Germany

4-7 Septembrie

2011

Travel Grant City of Glasgow – 15th Congress of the European Society for Organ

Transplantation 22nd

Annual BSHI Conference, Glasgow, United Kingdom

18-22 Aprilie 2012 Registration Bursary - International Liver CongressTM 2012 by EASL, Barcelona, Spain

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 10 / 18

Premii Nationale (24)

13-16 Iunie 2002 Mentiune pentru lucrarea “Importanta investigatiilor biochimice la pacientii cirotici cu

infectie spontana a lichidului de ascita care suprapun sindrom hepatorenal” prezentata in

cadrul Simpozionului National de Gastroenterologie, Cluj 2002

24-27 Septembrie

2003

Premiul pentru cea mai buna lucrare prezentata in cadrul celui de-al XXIV-lea Simpozion

National de Gastroenterologie, Hepatologie si Endoscopie Digestiva, Craiova 2003:

“Epidemiology of inflammatory bowel disease in adult population in Romania”

24-27 Septembrie

2003

Premiul Poster pentru lucrarea prezentata la cel de XXIV-lea Simpozion National de

Gastroenterologie, Hepatologie si Endoscopie Digestiva, Craiova 2003:“Death predicting

factors on the waiting list for liver transplantation”

1-3 Septembrie

2004

Premiul II – Postere la cel de-al XXV-lea Simpozion National de Gastroenterologie,

Hepatologie si Endoscopie Digestiva, Constanta 2004, pentru lucrarea: “Efficacy of

prophylactic banding ligation of high risk esophageal varices in cirrhotic patients on the

waiting list for liver transplantation”

11-14 Noiembrie

2004

Mentiune pentru Concursul pe teme de Nutritie Clinica organizat de Fresenius Kabi

Romania

15-17 Iunie 2006 Prize for the best oral presentation – section “Viral hepatitis, new techniques, varia”, The

XXVIIth National Symposium of Gastroenterology, Hepatology and Gastrointestinal

Endoscopy, Poiana Brasov, Romania

18-19 Aprilie 2008 Mentiune pentru prezentare sub forma de Poster la Congresul Anual al Asociatiei

Medicale Române, 18-19 Apilie 2008; Academia Romana, Bucuresti –“ Evaluarea

elastografică în timp real a pacienţilor cu hepatită C recurentă posttransplant hepatic”

18-20 Iunie 2008 Premiul II al SRGH pentru lucrarea prezentata la al XXIX-lea Simpozion National de

Gastroenterologie, Hepatologie si Endoscopie Digestiva, Cluj-Napoca 2009: “ ASCA and

ANCA serology in Romanian IBD Patients”.

18-20 Iunie 2008 Premiul II al SRGH pentru posterul prezentat la al XXIX-lea Simpozion National de

Gastroenterologie, Hepatologie si Endoscopie Digestiva, Cluj-Napoca 2009: “The prevalence

of anti-hepatitis B core antibodies in Romania.”

18-20 Iunie 2008 Premiul II al SRGH pentru lucrarea prezentata oral la al XXIX-lea Simpozion National

de Gastroenterologie, Hepatologie si Endoscopie Digestiva, Cluj-Napoca 2009: “ Prediction

of death on large waiting lists for liver transplantation using MELD exceptions.”

27-28 November

2008

Premiul I – Postere. Sesiunea Stiintifica a Institutului Clinic Fundeni si a Institutului de Boli

Cardiovasculare Prof. Dr. C. C. Iliescu: Investigarea profilului de expresie a genelor

implicate in medierea reactiilor inflamatorii la pacientii cu IBD utilizand tehnica MLPA

27-28 Noiembrie

2008 Premiul III pentru prezentarea orala – “Elastografia in timp real – nou marker pentru

evaluarea fibrozei hepatice la pacientii cu hepatita cronica C recurenta post transplant

hepatic”, Scientific Meeting of Fundeni Clinical Institute, 27-28 November 2008,

Bucharest

18 – 20 Iunie 2009 Premiul III pentru prezentarea orala – “Factori de risc ai recurentei carcinomului

hepatocelular dupa tratamentul chirurgical”, The XXIXth National Symposium of

Gastroenterology, Hepatology and Gastrointestinal Endoscopy, Cluj-Napoca, Romania

19-21 Mai 2011 Premiul III al SRGH pentru lucrarea: “Poate fi utilizat polimorfismul genei IL28B pentru

predictia raspunsului virusologic precoce la pacienti cu hepatita recurenta post transplant

Hepatic?”.al XXXI-lea Simpozion National de Gastroenterologie, Hepatologie si Endoscopie

Digestiva

26 Aprilie 2012

Premiul “Eugen Proca”/2011 pentru Stiinte Medicale pentru cartea “Transplantul

hepatic”, Editura Medicala, Bucuresti, 2011, Academia Oamenilor de Stiinta din Romania

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 11 / 18

ACTIVITATEA

DE

CERCETARE

STIINTIFICA:

PROIECTE DE

CERCETARE-

DEZVOLTARE

TITLU (ACRONIM) Perioa

da Functie

20 Ianuarie 2013 Gala Premiile MEDICA ACADEMICA, Editia a 4a, Premiul oferit de Fundatia “Nicolae

Cajal” pentru cea mai buna realizare in domeniul cercetarii fundamentale in medicina,

Bucuresti

12-15 Iunie 2013 Premiul I al Societatii Romane de Gastroenterologie pentru lucrarea prezentata in cadrul

celui de-al XXXIII-lea Congres National de Gastroenterologie, Hepatologie si Endoscopie

Digestiva, Timisoara 2013: Expresia genica cantitativa a factorilor de transcriptie hepatici

poate fi utilizata pentru predictia recurentei tumorale la pacientii cu hepatocarcinom tratati cu

viza curativa

12-14 Iunie 2014 Premiul SRGH pentru cea mai buna prezentare orala: „Profilul de expresie genica al

genelor specifice celulelor stem/progenitoare hepatice in hepatocarcinom si semnificatiile

prognostice”, Al XXXIV-lea Congres National de Gastroenterologie, Hepatologie si

Endoscopie Digestiva, Oradea

13 Iunie 2014 Diploma de Tanar Cercetator pentru merite deosebite in activitatea de cercetare din partea

Societatii Romane de Gastroenterologie si Hepatologie, Al XXXIV-lea Congres National de

Gastroenterologie, Hepatologie si Endoscopie Digestiva, Oradea

1-4 Aprilie 2015 Premiul „Herbert Beller Barbu” pentru tineri cercetatori pentru lucrarea prezentata in

cadrul celui de-al X-lea Simpozion „Acad. Nicolae Cajal”: “Deletia rs199508964 din exonul

6 al genei IRF5 se coreleaza cu polimorfismul genei Il28B rs12980275 si prezice raspunsul

virusologic sustinut la pacientii cu hepatita recurenta C post-transplant hepatic”.

17 Aprilie 2015 Diploma de Excelenta – cu ocazia aniversarii in Romania a 15 ani de transplant hepatic si

600 de operatii efectuate cu success (2000-2015)

30 Septembrie

2015

Diploma de Excelenta si Recunostinta pt profesionalism si daruire in ingrijirea pacientilor

Institutului Clinic Fundeni - Zilele Institutului Clinic Fundeni 2015

29 Aprilie 2016 Premiul I pentru Posterul prezentat in cadrul cursului 3rd UpDate on Hepatology, Course

Bucharest 2016, Romania, 28-29 Aprilie 2016, Bucuresti, Romania – „Clinical Challenges,

Unmet Needs and Emerging Therapies in Hepatology” cu titlul: „Hepatocyte telomerase

expression in hepatocellular carcinoma and chronic liver disease”

2018 Premiul II pentru Prezentarea Orala „Factori predicivi pentru regresia cirozei hepatice la

un an dupa eradicarea VHC”. In cadrul Mesei Rotunde “Lucrari originale”. Al 38-lea

Congres National de Gastroenterologie, Hepatologie si Endoscopie Digestiva, 24-26 Mai

2018, Craiova, Romania

2019 Premiul I pentru Posterul cu titlul „Metabolic syndrome in liver transplant recipients – The

role of genetic testing and blood based biomarkers” prezentat in cadrul cursului „6th Update

on Hepatology Course”, 5-6 Aprilie 2019, Bucuresti

2019 Winner of the Academic Debate cu titlul ”Controversy 1. Liver transplant beyond Milan

criteria. Pro.” din cadrul celui de al 39-lea Congres National de Gastroenterologie,

Hepatologie si Oncologie Digestiva, 6-8 iunie 2019, Timisoara, Romania

2019 Medalia Jubiliara „1000 de transplanturi hepatice in Romania” din cadrul Congresului

National al Asociatiei Romane de Chirurgie Hepato-bilio-pancreatica si Transplant hepatic,

25-28 Septembrie, Iasi

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 12 / 18

-INOVARE

OBTINUTE

PRIN

COMPETITIE

PE BAZA DE

CONTRACT/G

RANT

Grant/Proiect National

1.

Proiect VIASAN 324/2004. Rolul evidentei

computerizate a pacientilor in identificarea

potentialilor candidati pentru transplantul hepatic

si in urmarirea dinamicii listei de asteptare

(HEPASIST). Buget: 920000000 ROL

2004-

2006 Cercetator

2.

Proiect VIASAN 322/2004. Rolul manometriei

esofagiene in diagnosticul achalasiei la pacientii

cu disfagie si in evaluarea eficientei

tratamentului endoscopic sau chirurgical al

afectiunii (ROMAC). Buget: 1265000000 ROL

2004-

2006 Cercetator

3.

Proiect VIASAN 428/2004. Evidenta

computerizata prospectiva a pacientilor cu risc

pentru dezvoltarea cancerului colorectal la care

se impune screeningul si supravegherea

(COLOCANS). Buget: 920000000 ROL

2004-

2006 Cercetator

4.

Proiect CEEX 142/2006. Diagnosticul non-

invaziv si markeri de prognostic ai

hepatocarcinomului detectat in leziunile focale

nodulare din ciroza hepatica (PROSONOHEP).

Buget: 1500000 RON

2006-

2008 Cercetator

5.

Proiect CEEX 89/2006. Implicaţii diagnostice şi

prognostice ale aspectului endomicroscopic al

microvascularizaţiei leziunilor premaligne şi

maligne ale tubului digestiv superior

(DIAPROGENDO). Buget: 1500000 RON

2006-

2008 Cercetator

6.

Proiect CEEX 60/2006. Evaluarea fenotipica si

genotipica a pacientilor cu boli inflamatorii

intestinale cronice din Romania si generarea

unui registru biregional computerizat de urmarire

prospectiva (IBDPROSPECT). Buget: 1500000

RON

2006-

2008 Cercetator

7.

Proiect CEEX 65/2006. Potenţialul Terapeutic al

Celulelor Stem Hematopoietice în Afecţiunile

Hepatice (LIVERSTEM). Buget 1500000 RON

2006-

2008 Cercetator

8.

Proiect PNII 42170/2008 ENDONERD Valoarea

endomicroscopiei confocale laser si a

endoscopiei cu magnificatie, in banda ingusta

(NBI), in diagnosticul bolii de reflux

gastroesofagian nonerozive. Buget: 1521600

RON

2008-

2011 Cercetator

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 13 / 18

9.

Proiect PNII 42169/2008 GENOWIL Valoarea

diagnostica si prognostica a analizei genetice si

corelatii genotip-fenotip la pacientii cu boala

Wilson. Buget: 1963000 RON

2008-

2011 Cercetator

10.

Proiect 42162/2008 BAROFAT (Valoare totala)

Factori predictivi ai raspunsului serologic,

imagistic, imunohistochimic si histologic hepatic

la pacientii cu obezitate morbida si ficat gras

nonalcoolic supusi chirurgiei bariatrice. Buget:

1850000 RON

2008-

2011 Cercetator

11.

Proiect PNII- PCE 125/2011. Molecular

predictors of prognosis following curative

treatment of hepatocellular carcinoma – the

significance of liver stem/progenitor cells genes,

Buget: 1437500 RON

2011-

2016 Cercetator

12.

Proiect finantat prin programul „Cercetare in

domenii prioritare”, mecanismul financiar al

Spatiului Economic European (SEE). EEA-JRP

Romania-Norvegia Nr proiect 4SEE. Stratificarea

pacientilor cu carcinom hepatocelular prin

identificarea unor markeri neinvazivi. Buget:

1125000Eur, Co-finantare privata: 180916 EUR

2014-

2017 Cercetator

13

Proiect POCU/91/4/8/107931, finantat din fonduri

europene nerambursabile, implementat de catre

Institutul Clinic Fundeni din Bucuresti avand titlul

“Program de formare a personalului medical din

România în managementul pacienților infectați

cronic cu virusuri hepatitice B și C - HEPATER”

2018-

2020

Responsabil

curicula VHC

14

Proiect PN-III-P1-1.1-TE-2016-1109 “Effect of

immunosuppression agents on human hepatocyte

and non-parenchymal liver cells

apoptosis”(APOHEPI)

2018-

2020

Director

proiect

15 Proiect de mobilitate pentru cercetatori PN-III-P1-

1.1-MC-2018-1674 2018

Director

proiect

16

Proiect POCU/755/4/9/136208 finantat din fonduri

europene nerambursabile, implementat de catre

Institutul Clinic Fundeni din Bucuresti avand titlul

LIVE(RO)2-SUD: Program regional de prevenire,

screening și diagnostic al pacienților cu boli

hepatice cronice secundare infecțiilor virale cu

virusuri hepatice B/D și C

2020-

2023

Expert

macroregional

Studii multicentrice internationale

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 14 / 18

1

SR121463B in cirrhotic ascites treatment with

normonatremia: a placebo-controlled dose-

comparison study (NORMO-CAT)

2004 Co-

investigator

2

SR121463B in cirrhotic ascites treatment with

hyponatremia: a placebo-controlled dose-

comparison study (HYPO-CAT) (No LTS5634)

2004 Co-

investigator

3

SR121463B in cirrhotic ascites treatment with

hyponatremia: a single-blind, placebo-controlled,

long-term treatment study (EXPO-CAT) (No

LTS5634)

2004-

2006

Co-

investigator

4

Satavaptan in the prevention of ascites recurrence: a

double-blind, randomized, parallel-group

comparison of satavaptan at 5 to 10 mg daily vs

placebo in the absence of diuretics in patients with

recurrent ascites due to cirrhosis of the liver

(SPARe-2) (EFC 6682) (Phase III)

2006-

2008

Co-

investigator

5

Satavaptan cirrhotic ascites treatment study:a

double-blind, randomized, parallel-group

comparison of treatment with satavaptan at 5 to

10mg daily versus placebo on top of conventional

treatment in patients with ascites due to cirrhosis of

the liver (EFC 4492) (Phase III)

2006-

2008

Co-

investigator

6

Randomized, Multicenter, double-blinded, phase IV

study evaluating the efficacy (as measured by

sustained virological response) and safety of 360µg

induction dosing of Pegasys in combination with

higher Copegus doses in treatment naïve patients

with chronic hepatitis C genotype 1 virus infection

of high viral titer and baseline body weight greater

than or equal to 85kg (Protocol no NV18210A)

2006-

2008

Co-

investigator

7

A phase 3b, Randomized, Double-Blind, Double-

Dummy Study Evaluating the Antiviral Efficacy,

Safety and Tolerability of Tenofovir Disoproxil

Fumarate (DF) Monotherapy versus Emtricitabine

plus Tenofovir DF Fixed-Dose Combination

Therapy in Subjects with Chronic Hepatitis B who

are resistant to Lamivudine – GS-US-174-0121

2008-

2013

Co-

investigator

8

A phase III, randomized, double-blind trial to

evaluate the efficacy, safety and tolerability of

TMC435 vs telaprevir, both in combination with

PegIFN alpha 2a and ribavirin in chronic hepatitis C

genotype 1 infected subjects who were null or

partial responders to prior PegIFN alpha and

ribavirin therapy (ATTAIN Study,

TMC435HPC3001)

2012-

2014

Co-

investigator

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 15 / 18

9

A randomized, open-labeled study to evaluate the

efficacy and safety of ABT-450/Ritonavir/ABT-267

and ABT-333 co-adminstred with ribavirin

compared to telaprevir co-administred with

pegylated interferon α-2a and ribavirin in treatment-

experienced adults with chronic hepatitis C

genotype-1 virus infection (MALACHITE-II)

2013-

2015

Co-

investigator

10

An International, Multi-Center Study evaluating the

correlation of IL28B genotypes with chronic

hepatitis C disease characteristics and patient

demographics (MV25600)

2011-

2013

Co-

investigator

11

Non-Interventional Cohort Study on the Utilization

and Impact of Dual and Triple Therapies Based on

the Pegylated Interferon for the Treatment of

Chronic Hepatitis C (MV25599)

2012-

2014

Co-

investigator

12

A Phase III, Open-Label Clinical Trial to study the

efficacy and safety of the combination regimen of

MK-5172/MK-8742 versus Sofosbuvir/Pegylated

Interferon/Ribavirin (PR) in treatment-naive and PR

prior treatment failure subjects with chronic HCV

GT1, 4 or 6 infection (MK 5172-077)

2014-

2017

Co-

investigator

13

An Open-Label, Multicenter Study to evaluate long-

term outcomes with ABT-450/Ritonavir/ABT-267

(ABT-450/r/ABT-267) and ABT-333 with or

without ribavirin (RBV) in adults with genotype 1

chronic hepatitis C virus (HCV) infection (TOPAZ-

I) (M14-423)

2014-

2021

Co-

investigator

14

A Study of Glecaprevir (GLE)/Pibrentasvir (PIB) in

Treatment-Naive Adults With Chronic Hepatitis C

Virus (HCV) Genotype 1-6 Infection and

Compensated Cirrhosis (M16-135)

2017-

2018

Co-

investigator

15

A 52-week, placebo-controlled, randomized, Phase

3 study to evaluate the safety and efficacy of

seladelpar in subjects with primary biliary

cholangitis (PBC) and an inadequate response to or

an intolerance to ursodeoxycholic acid (UDCA)

(CB8025-31735)

2019-

2021

Co-

investigator

16

A Multicenter, Randomized, Double-Blind,

Placebo-Controlled Phase III Study to Evaluate

the Efficacy and Safety of Elafibranor in Patients

with Nonalcoholic Steatohepatitis (NASH) and

fibrosis (GFT505-315-1)

2017-

2020

Co-

investigator

17

A PHASE 3, MATRIX DESIGN,

PARTIALLY DOUBLE-BLIND,

RANDOMIZED STUDY OF THE

EFFICACY AND SAFETY OF 50 MG

LONAFARNIB/ 100 MG RITONAVIR BID

WITH AND WITHOUT 180 MCG PEG IFN-

2020-

2022

Co-

investigator

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 16 / 18

ALFA-2A FOR 48 WEEKS COMPARED

WITH PEG IFN-ALFA-2A MONOTHERAPY

AND PLACEBO TREATMENT IN

PATIENTS CHRONICALLY INFECTED

WITH HEPATITIS DELTA VIRUS BEING

MAINTAINED ON ANTI-HBV

NUCLEOS(T)IDE THERAPY (D-LIVR

PROTOCOL NUMBER: EIG-LNF-01

Studii multicentrice nationale

1

Observational, retrospective cohort study to

evaluate pretreatment and on treatment predictors of

response to peginterferon alfa and ribavirin therapy

in chronic viral Hepatitis C in real life medical

practice in Romania (HERO 1) – protocol ML

21909

2008-

2009

Co-

investigator

PUBLICATII

Indice Hirsch ISI Web of Science Core Colection (22.03.2021): 19

Nr Citari ISI Web of Science (22.03.2021): citari totale 1099

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 17 / 18

Lista Completa de Lucrari:

I. Lista lucrarilor semnificative:

1. Speranta Iacob, Vito R. Cicinnati, Philip Hilgard, Razvan A. Iacob, Liana S. Gheorghe, Irinel

Popescu, Andrea Frilling, Massimo Malago, Guido Gerken, Christoph E. Broelsch, Susanne

Beckebaum. Predictors of graft and patient survival in HCV recipients - model to predict HCV

cirrhosis following liver transplantation. Transplantation 2007; 84:56-63

2. Cicinnati VR, Iacob S, Klein CG, Baba HA, Sotiropoulos GC, Hilgard P, Erim Y, Broelsch CE,

Gerken G, Beckebaum S. Ribavirin with either standard or pegylated interferon to treat recurrent

hepatitis C after liver transplantation. Aliment Pharmacol Ther 2007; 26:291-303

3. Speranta Iacob, Liana Gheorghe, Doina Hrehoret, Gabriel Becheanu, Vlad Herlea, Irinel Popescu.

Pegylated Interferon α-2a and Ribavirin Combination Therapy in HCV Liver Transplant

Recipients. Experience of 7 Cases. J Gastrointestin Liver Dis 2008; 17:165-172

4. Iacob S, Gheorghe L, Iacob R, Gheorghe C, Hrehoret D, Popescu I. MELD exceptions and new

predictive score of death on long waiting lists for liver transplantation. Chirurgia (Bucur)

2009;104: 267-273

5. Beckebaum S, Iacob S, Klein CG, Dechêne A, Varghese J, Baba HA, Sotiropoulos GC, Paul A,

Gerken G, Cicinnati VR. Assessment of Allograft Fibrosis by Transient Elastography and

Noninvasive Biomarker Scoring Systems in Liver Transplant Patients. Transplantation.

2010;89:983-93

6. Beckebaum S, Iacob S, Sweid D, Sotiropoulos GC, Saner F, Kaiser G, Radtke A, Klein CG, Erim

Y, de Geest S, Paul A, Gerken G, Cicinnati VR. Efficacy, safety, and immunosuppressant

adherence in stable liver transplant patients converted from a twice-daily tacrolimus-based

regimen to once-daily tacrolimus extended-release formulation. Transpl Int 2011;24:666-75

7. Iacob S, Cicinnati VR, Dechêne A, Lindemann M, Heinemann FM, Rebmann V, Ferencik S,

Sotiropoulos GC, Popescu I, Horn PA, Gerken G, Paul A, Beckebaum S. Genetic, immunological

and clinical risk factors for biliary strictures following liver transplantation. Liver Int. 2012;

32(8):1253-61

8. Xu L, Beckebaum S, Iacob S, Wu G, Kaiser GM, Radtke A, Liu C, Kabar I, Schmidt HH, Zhang

X, Lu M, Cicinnati VR. MicroRNA-101 inhibits human hepatocellular carcinoma progression

through EZH2 downregulation and increased cytostatic drug sensitivity. J Hepatol. 2014;

60(3):590-8

9. Iacob S, Cicinnati VR, Lindemann M, Heinemann FM, Radtke A, Kaiser GM, Kabar I, Schmidt

HH, Baba HA, Beckebaum S. Donor-Specific Anti-HLA Antibodies and Endothelial C4d

Deposition-Association With Chronic Liver Allograft Failure. Transplantation. 2015;

99(9):1869-75

10. Iacob S, Ester C, Lita M, Ratziu V, Gheorghe L. Real-life perception and practice patterns of

NAFLD/NASH in Romania: results of a survey completed by 102 board-certified

gastroenterologists. J Gastrointestin Liver Dis. 2016;25(2):183-90

11. L. Gheorghe, I. Sporea, S. Iacob, R. Şirli, A. Trifan, D. Dobru, M. Diculescu, C. Stanciu, O. Pascu,

M. Acalovschi, C. Brisc, C. Cijevschi, C. Gheorghe, Z. Spârchez, I. Rogoveanu, D. Dumitrascu.

Position paper on treatment of hepatitis C in Romania, 2017. Part one. J Gastrointestin Liver Dis.

2017;26(2):171-81 (Corresponding author)

12. Gheorghe L, Sporea I, Iacob S, Sirli R, Trifan A, Diculescu M, Stanciu C, Pascu O, Acalovschi M,

Brisc C, Cijevschi C, Gheorghe C, Spârchez Z, Rogoveanu I, Dobru D, Dumitrascu DL. Position

Paper on Treatment of Hepatitis C in Romania 2017. Part Two. J Gastrointestin Liver Dis.

2017;26(3):309-317. (Corresponding author)

Curriculum Vitae Iacob Maria Speranta

© Uniunea Europeană, 2002-2013 | http://europass.cedefop.europa.eu Pagina 18 / 18

13. Gheorghe L, Iacob S, Curescu M, Brisc C, Cijevschi C, Caruntu F, Stanciu C, Simionov I, Sporea

I, Gheorghe C, Iacob R, Arama V, Sirli R, Trifan A. Real-Life Use of 3 Direct-Acting Antiviral

Regimen in a Large Cohort of Patients with Genotype-1b HCV Compensated Cirrhosis. J

Gastrointestin Liver Dis. 2017;26(3):275-281. (Corresponding author)

14. Dorobantu B, Popescu I, Dima S, Nastase A, Iacob S. Molecular Biomarkers as Predictors for

Biliary Complications Following Liver Transplantation. A Prospective Study. J Gastrointestin

Liver Dis. 2017;26(3):253-259.

15. Iacob S, Cerban R, Pietrareanu C, Ester C, Iacob R, Gheorghe C, Popescu I, Gheorghe L. 100%

Sustained Virological Response and Fibrosis Improvement in Real-Life Use of Direct Acting

Antivirals in Genotype-1b Recurrent Hepatitis C following Liver Transplantation. J Gastrointestin

Liver Dis. 2018;27(2):139-144

16. Iacob S, Ghioca M, Csiki IE, Tomescu D, Droc G, Hrehoret D, Brasoveanu V, Pietrareanu C, Iacob

R, Gheorghe C, Popescu I, Gheorghe L. Pre and post-liver transplant outcome of cirrhotic patients

with acute on chronic liver failure. Medicine 2020; Vol:No 44(e22419)

II. Teza de Doctorat:

Titlul Tezei de Doctorat: „Hepatita recurenta C posttransplant hepatic – strategii terapeutice si factori

asociati cu recurenta severa”. Coordonator: Prof. Dr. Irinel Popescu

III. Carti si Capitole din Carti: 31

IV. Articole /studii in extenso publicate in reviste cotate ISI: 67

V. Articole /studii publicate in extenso in jurnale indexate BDI: 27

VI. Articole /studii publicate in extenso cu caracter educational: 12

VII. Rezumate ale lucrarilor prezentate la conferinte internationale de specialitate, publicate in reviste

cotate ISI: 301

VIII. Rezumate publicate in Reviste/volumele unor manifestari stiintifice cu ISBN/ISSN: 74

IX.Conferinte invitate la manifestari stiintifice Internationale si Nationale: 55

X.Alte lucrari si contributii Stiintifice.

A.Prezentari orale la manifestari stiintifice internationale: 29

B.Prezentari orale la manifestari stiintifice nationale: 113

C.Prezentari sub forma de poster: 388